TABLET FORMULATIONS OF VIABLE LACTIC ACID BACTERIA
Institute of Pharmaceutical Technology and Biopharmaceutics, University of Vienna, Althanstraβe 14, A-1090, Vienna, Austria
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Author to whom correspondence should be addressed.
Sci. Pharm. 2001, 69(3), 249-255; https://doi.org/10.3797/scipharm.aut-01-195
Submission received: 2 June 2001
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Accepted: 1 September 2001
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Published: 23 September 2001
Abstract
The aim of this work was to develop a gastric juice-resistant tablet formulation of viable lactic acid bacteria (LAB). As excipients, hydroxypropyl-methylcellulose acetate succinate (HPMCAS) and sodium alginate were applied to enhance gastric juice-resistance, and Avicel® as used to modifytablet disintegration in the intestine. The formulation was optimized using statistical experimental
design methodology. The influence of the relevant process variables (amounts of excipients applied and compaction force) on the loss of viable cells during the tablet production, on acid stability, and on tablet disintegration time was investigated. It was found that the content of HPMCAS and the compaction force were the most important test variables for tablet preparation. They influence the
loss of bacteria during the tableting process, gastric juice resistance, and the disintegration time of tablets after incubation in artificial intestinal fluid. Avicel® had little influence on all three test parameters, while sodium alginate only affected disintegration time in phosphate buffer pH 6.8.
design methodology. The influence of the relevant process variables (amounts of excipients applied and compaction force) on the loss of viable cells during the tablet production, on acid stability, and on tablet disintegration time was investigated. It was found that the content of HPMCAS and the compaction force were the most important test variables for tablet preparation. They influence the
loss of bacteria during the tableting process, gastric juice resistance, and the disintegration time of tablets after incubation in artificial intestinal fluid. Avicel® had little influence on all three test parameters, while sodium alginate only affected disintegration time in phosphate buffer pH 6.8.
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MDPI and ACS Style
Stadler, M.; Viernstein, H. TABLET FORMULATIONS OF VIABLE LACTIC ACID BACTERIA. Sci. Pharm. 2001, 69, 249-255. https://doi.org/10.3797/scipharm.aut-01-195
AMA Style
Stadler M, Viernstein H. TABLET FORMULATIONS OF VIABLE LACTIC ACID BACTERIA. Scientia Pharmaceutica. 2001; 69(3):249-255. https://doi.org/10.3797/scipharm.aut-01-195
Chicago/Turabian StyleStadler, M., and H. Viernstein. 2001. "TABLET FORMULATIONS OF VIABLE LACTIC ACID BACTERIA" Scientia Pharmaceutica 69, no. 3: 249-255. https://doi.org/10.3797/scipharm.aut-01-195
