A VALIDATED HPLC-ASSAY FOR THE DETERMINATION OF MELOXICAM IN PRESENCE OF ITS DEGRADATION PRODUCTS
Institute of Pharmaceutical Chemistry, University of Vienna A-1 090 Wien, Althanstraße 14, Austria
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Author to whom correspondence should be addressed.
Sci. Pharm. 2004, 72(3), 213-220; https://doi.org/10.3797/scipharm.aut-04-17
Submission received: 12 July 2004
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Revised: 13 August 2004
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Accepted: 13 August 2004
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Published: 3 September 2004
Abstract
The stability of aqueous solutions of meloxicam is studied with samples of different concentrations, and in different containers. Quantitation is carried out utilizing a validated stability indicating HPLC assay with five-point calibration. Sample solutions of meloxicam of three different concentrations (2 mg ml−1; 250 µg ml−1; 40 µg ml−1) are subjected to simulated sunlight and tested for stability. A distinct correlation of the photodegradation rate with the concentration of the sample solution was found. Furthermore, the influence of size and geometry of the containers in which the solutions were exposed to light was investigated and results compared.
Keywords:
meloxicam; HPLC; artificial sunlight; photostability
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MDPI and ACS Style
Bartsch, H.; Eiper, A.; Kopelent-Frank, H.; Procházka, J. A VALIDATED HPLC-ASSAY FOR THE DETERMINATION OF MELOXICAM IN PRESENCE OF ITS DEGRADATION PRODUCTS. Sci. Pharm. 2004, 72, 213-220. https://doi.org/10.3797/scipharm.aut-04-17
AMA Style
Bartsch H, Eiper A, Kopelent-Frank H, Procházka J. A VALIDATED HPLC-ASSAY FOR THE DETERMINATION OF MELOXICAM IN PRESENCE OF ITS DEGRADATION PRODUCTS. Scientia Pharmaceutica. 2004; 72(3):213-220. https://doi.org/10.3797/scipharm.aut-04-17
Chicago/Turabian StyleBartsch, Herbert, Angelika Eiper, Hannelore Kopelent-Frank, and Jiři Procházka. 2004. "A VALIDATED HPLC-ASSAY FOR THE DETERMINATION OF MELOXICAM IN PRESENCE OF ITS DEGRADATION PRODUCTS" Scientia Pharmaceutica 72, no. 3: 213-220. https://doi.org/10.3797/scipharm.aut-04-17
