Nanosized Particles of Synthetic Silicon Dioxide Delay the Regeneration of Gastric Ulcers Created by N-Methyl-N′-Nitro-N-Nitrosoguanidine and Induce Hyper-Trophic Gastritis-like Symptoms
Abstract
:1. Introduction
2. Materials and Methods
2.1. Silica Particles
2.2. Animals
2.3. MNNG and Silica Particle Injection into the Submucosa of the Stomach
2.4. Oral Gavage Administration of Silica Particles
2.5. Preparation and Observation of the HE- and Azan-Stained Specimens
2.6. Experimental Frequency and Statistical Analysis
3. Results and Discussion
3.1. Hypertrophic Gastritis-like Lesions form Due to Exposure to Amorphous Nanosilica during the Healing Process of Gastric Ulcers
3.2. Amorphous Nanosilica Not Only Delays the Healing of Gastric ulcers but also Induces Fibrosis on the Surface of the Gastric Mucosa
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Iwasaki, A.; Kawai, Y.; Onodera, A. Nanosized Particles of Synthetic Silicon Dioxide Delay the Regeneration of Gastric Ulcers Created by N-Methyl-N′-Nitro-N-Nitrosoguanidine and Induce Hyper-Trophic Gastritis-like Symptoms. Sci. Pharm. 2024, 92, 20. https://doi.org/10.3390/scipharm92020020
Iwasaki A, Kawai Y, Onodera A. Nanosized Particles of Synthetic Silicon Dioxide Delay the Regeneration of Gastric Ulcers Created by N-Methyl-N′-Nitro-N-Nitrosoguanidine and Induce Hyper-Trophic Gastritis-like Symptoms. Scientia Pharmaceutica. 2024; 92(2):20. https://doi.org/10.3390/scipharm92020020
Chicago/Turabian StyleIwasaki, Ayaka, Yuichi Kawai, and Akira Onodera. 2024. "Nanosized Particles of Synthetic Silicon Dioxide Delay the Regeneration of Gastric Ulcers Created by N-Methyl-N′-Nitro-N-Nitrosoguanidine and Induce Hyper-Trophic Gastritis-like Symptoms" Scientia Pharmaceutica 92, no. 2: 20. https://doi.org/10.3390/scipharm92020020