Correction: Díaz-Talavera et al. PrimPol: A Breakthrough among DNA Replication Enzymes and a Potential New Target for Cancer Therapy. Biomolecules 2022, 12, 248
Acknowledgments
References
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Residue | Function | Activity Involved [Ref.] | Somatic Mutations in Cancer (COSMIC Database) |
---|---|---|---|
R47 | Contact the DNA template | Primase/polymerase [107,112] | - |
*R76 | Contact the DNA template | Primase/polymerase [107,112] | R76H and R76C |
Y100 | Steric gate (sugar selector) | Primase/polymerase [74] | Y100H |
D114 | Cation ligand (Mn2+ or Mg2+) | Primase/polymerase [12,79,107] | - |
E116 | Cation ligand (Mn2+ or Mg2+) | Primase/polymerase [12,79,107] | - |
H169 | Stabilize the 3′ nucleotide | Primase/polymerase [12,107] | - |
L200-S260 | PolDIP2 binding | Primase?/polymerase [116] | G201D, E203K, D204G, A208S, A208T, H214Y, P217S, P217L, H218Y, F219L, S220L, Q226L, K232T, M233I, T235R, W243S, T244A, G254W, SS59R |
D280 | Cation ligand | Primase/polymerase [12,79,107] | - |
R291 | Stabilize the 3′ nucleotide | Primase/polymerase [107,111] | R291W |
*R417 | - | - | R417L, R417W and R417Q |
C419, H426,C446 and C451 | Zn2+ ligand | Primase [12,113] | H426N and H426R |
D519/F522 and D551/I554 | Binding of RPA | Primase/polymerase [117] | F522V |
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Díaz-Talavera, A.; Montero-Conde, C.; Leandro-García, L.J.; Robledo, M. Correction: Díaz-Talavera et al. PrimPol: A Breakthrough among DNA Replication Enzymes and a Potential New Target for Cancer Therapy. Biomolecules 2022, 12, 248. Biomolecules 2022, 12, 693. https://doi.org/10.3390/biom12050693
Díaz-Talavera A, Montero-Conde C, Leandro-García LJ, Robledo M. Correction: Díaz-Talavera et al. PrimPol: A Breakthrough among DNA Replication Enzymes and a Potential New Target for Cancer Therapy. Biomolecules 2022, 12, 248. Biomolecules. 2022; 12(5):693. https://doi.org/10.3390/biom12050693
Chicago/Turabian StyleDíaz-Talavera, Alberto, Cristina Montero-Conde, Luis Javier Leandro-García, and Mercedes Robledo. 2022. "Correction: Díaz-Talavera et al. PrimPol: A Breakthrough among DNA Replication Enzymes and a Potential New Target for Cancer Therapy. Biomolecules 2022, 12, 248" Biomolecules 12, no. 5: 693. https://doi.org/10.3390/biom12050693