Concentrations of Bioelements (Zn, Cu, Fe, Cr, Mg, Mn) in Serum and Bone Tissue of Aging Men Undergoing Hip Arthroplasty: Implications for Erectile Dysfunction
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Participants
2.2. Division into Groups
2.3. Measurement of Sex Hormones
2.4. Measurement of Bioelements
2.5. Statistical Analysis
3. Results
4. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Patients without Erectile Dysfunction | Patients with Erectile Dysfunction | p | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
Variable | X | Minimum | Maximum | SD | X | Minimum | Maximum | SD | ||
Age | 62.86 | 60.00 | 72.00 | 3.68 | 65.76 | 60.00 | 75.00 | 4.32 | 0.068 | |
BMI | 30.03 | 21.91 | 37.89 | 4.32 | 29.44 | 14.99 | 42.97 | 4.24 | 0.695 | |
IIEF | 22.86 | 22.00 | 25.00 | 1.03 | 15.94 | 5.00 | 21.00 | 3.85 | <0.001 * | |
Serum levels | TT ng/mL | 6.03 | 3.68 | 8.53 | 1.58 | 4.86 | 1.38 | 12.90 | 2.27 | 0.009 * |
FT ng/mL | 0.09 | 0.03 | 0.16 | 0.04 | 0.09 | 0.02 | 0.23 | 0.04 | 0.634 | |
BioT ng/dL | 2.12 | 0.97 | 3.87 | 0.85 | 1.94 | 0.42 | 5.06 | 0.93 | 0.411 | |
E2 pg/mL | 88.04 | 20.92 | 170.83 | 37.31 | 83.96 | 28.26 | 180.53 | 36.29 | 0.569 | |
Zn | 1.29 | 1.07 | 1.99 | 0.24 | 1.43 | 0.23 | 3.04 | 0.44 | 0.320 | |
Cu | 1.00 | 0.76 | 1.40 | 0.16 | 0.97 | 0.25 | 1.45 | 0.18 | 0.844 | |
Fe | 1.82 | 0.94 | 3.05 | 0.58 | 1.52 | 0.32 | 3.45 | 0.51 | 0.062 | |
Cr | 0.008 | 0.002 | 0.01 | 0.003 | 0.01 | 0.006 | 0.002 | 0.001 | 0.222 | |
Mg | 24.86 | 19.07 | 30.63 | 3.08 | 26.25 | 16.95 | 68.24 | 6.98 | 0.785 | |
Mn | 0.01 | 0.01 | 0.01 | 0.00 | 0.01 | 0.00 | 0.02 | 0.00 | 0.086 | |
Bone levels | Mg | 3459.61 | 1501.77 | 5330.19 | 1299.42 | 3812.53 | 1220.72 | 10,255.82 | 1610.36 | 0.644 |
Mn | 0.27 | 0.05 | 0.88 | 0.26 | 0.62 | 0.07 | 5.08 | 0.95 | 0.142 | |
Zn | 185.34 | 82.08 | 333.76 | 71.02 | 193.93 | 68.08 | 306.45 | 47.66 | 0.543 | |
Cu | 1.42 | 0.17 | 4.19 | 1.02 | 1.51 | 0.23 | 7.45 | 1.11 | 0.906 | |
Fe | 97.55 | 6.89 | 307.47 | 81.16 | 146.43 | 0.59 | 1112.01 | 193.71 | 0.531 | |
Cr | 1.85 | 0.20 | 10.67 | 2.95 | 4.05 | 0.07 | 101.00 | 15.10 | 0.694 |
Effect | Patients without Erectile Dysfunction | Patients with Erectile Dysfunction | |||||||
---|---|---|---|---|---|---|---|---|---|
p | −95.00% CI | +95.00% CI | Beta | p | −95.00% CI | +95.00% CI | Beta | ||
BioT | Zn | 0.049 * | −3.730 | 0.922 | −0.393 | 0.019 * | 0.113 | 1.229 | 0.325 |
Cu | 0.102 | −5.531 | 0.625 | −0.473 | 0.019 * | −2.820 | −0.268 | −0.298 | |
Fe | 0.666 | −1.248 | 0.848 | −0.136 | 0.453 | −0.585 | 0.265 | −0.089 | |
Cr | 0.050 * | −15.362 | 383.479 | 0.692 | 0.007 * | 42.650 | 258.414 | 0.401 | |
Mg | 0.913 | −0.188 | 0.207 | 0.034 | 0.112 | −0.056 | 0.006 | −0.190 | |
Mn | 0.778 | −404.126 | 314.890 | −0.091 | 0.107 | −148.207 | 14.932 | −0.248 | |
TT | Zn | 0.066 | −7.622 | 0.325 | −0.548 | 0.171 | −0.444 | 2.437 | 0.196 |
Cu | 0.199 | −2.104 | 8.414 | 0.327 | 0.168 | −5.554 | 0.988 | −0.181 | |
Fe | 0.791 | −1.582 | 2.000 | 0.076 | 0.374 | −1.601 | 0.612 | −0.111 | |
Cr | 0.151 | −108.659 | 572.781 | 0.468 | 0.025 * | 40.784 | 598.937 | 0.344 | |
Mg | 0.027 * | 0.062 | 0.738 | 0.782 | 0.300 | −0.123 | 0.039 | −0.129 | |
Mn | 0.479 | −808.340 | 420.138 | −0.211 | 0.031 * | −446.563 | −22.025 | −0.349 | |
FT | Zn | 0.131 | −0.150 | 0.024 | −0.400 | 0.023 * | 0.004 | 0.053 | 0.316 |
Cu | 0.054 * | −0.228 | 0.002 | −0.493 | 0.009 * | −0.133 | −0.020 | −0.335 | |
Fe | 0.611 | −0.048 | 0.030 | −0.137 | 0.335 | −0.028 | 0.010 | −0.115 | |
Cr | 0.033 * | 0.878 | 15.822 | 0.711 | 0.012 * | 1.409 | 10.931 | 0.373 | |
Mg | 0.866 | −0.008 | 0.007 | −0.045 | 0.137 | −0.002 | 0.000 | −0.178 | |
Mn | 0.760 | −15.278 | 11.663 | −0.083 | 0.187 | −5.997 | 1.203 | −0.202 | |
E2 | Zn | 0.253 | −140.542 | 43.543 | −0.308 | 0.961 | −21.902 | 20.867 | −0.006 |
Cu | 0.441 | −163.902 | 79.739 | −0.184 | 0.474 | −66.894 | 31.507 | −0.087 | |
Fe | 0.691 | −48.768 | 34.205 | −0.113 | 0.028 * | −34.897 | −2.041 | −0.263 | |
Cr | 0.490 | −5462.650 | 10,322.246 | 0.207 | 0.001 * | 2878.157 | 11,154.738 | 0.477 | |
Mg | 0.009 * | 4.074 | 19.737 | 0.984 | 0.041 * | 0.051 | 2.465 | 0.243 | |
Mn | 0.695 | −16,686.765 | 11,769.718 | −0.113 | 0.622 | −3933.646 | 2372.927 | −0.074 |
Effect | Patients without Erectile Dysfunction | Patients with Erectile Dysfunction | |||||||
---|---|---|---|---|---|---|---|---|---|
p | −95.00% CI | +95.00% CI | Beta | p | −95.00% CI | +95.00% CI | Beta | ||
TT | Mg | 0.078 | −0.009 | 0.001 | −3.326 | 0.086 | −0.002 | 0.000 | −0.370 |
Mn | 0.300 | −14.177 | 5.679 | −0.668 | 0.477 | −1.372 | 2.874 | 0.292 | |
Zn | 0.072 | −0.008 | 0.129 | 2.716 | 0.266 | −0.010 | 0.035 | 0.231 | |
Cu | 0.043 * | 0.327 | 12.129 | 3.876 | 0.897 | −1.694 | 1.490 | −0.050 | |
Fe | 0.958 | −0.042 | 0.041 | −0.041 | 0.697 | −0.012 | 0.008 | −0.161 | |
Cr | 0.037 * | −4.337 | −0.228 | −4.157 | 0.988 | −0.482 | 0.489 | 0.006 | |
FT | Mg | 0.985 | 0.000 | 0.000 | 0.051 | 0.003 * | 0.000 | 0.000 | −0.520 |
Mn | 0.385 | −0.260 | 0.541 | 0.980 | 0.001 * | 0.032 | 0.094 | 0.937 | |
Zn | 0.940 | −0.003 | 0.003 | −0.159 | 0.012 * | 0.000 | 0.001 | 0.435 | |
Cu | 0.281 | −0.131 | 0.345 | 2.945 | 0.230 | −0.009 | 0.036 | 0.360 | |
Fe | 0.321 | −0.002 | 0.001 | −1.506 | 0.005 * | 0.000 | 0.000 | −0.660 | |
Cr | 0.321 | −0.117 | 0.049 | −2.732 | 0.032 * | −0.015 | −0.001 | −0.673 | |
BioT | Mg | 0.946 | −0.004 | 0.005 | 0.180 | 0.002 * | −0.001 | 0.000 | −0.546 |
Mn | 0.309 | −5.291 | 12.942 | 1.164 | 0.001 * | 0.673 | 2.064 | 0.902 | |
Zn | 0.897 | −0.066 | 0.060 | −0.273 | 0.008 * | 0.003 | 0.017 | 0.460 | |
Cu | 0.257 | −2.841 | 7.996 | 3.106 | 0.222 | −0.196 | 0.812 | 0.365 | |
Fe | 0.253 | −0.056 | 0.020 | −1.762 | 0.006 * | −0.008 | −0.001 | −0.647 | |
Cr | 0.265 | −2.767 | 1.006 | −3.106 | 0.027 * | −0.341 | −0.023 | −0.696 | |
E2 | Mg | 0.416 | −0.088 | 0.173 | 1.749 | 0.133 | −0.023 | 0.003 | −0.325 |
Mn | 0.654 | −312.939 | 220.115 | −0.371 | 0.588 | −22.973 | 39.880 | 0.225 | |
Zn | 0.525 | −2.312 | 1.385 | −1.059 | 0.539 | −0.230 | 0.431 | 0.128 | |
Cu | 0.980 | −156.928 | 159.906 | 0.047 | 0.607 | −17.710 | 29.839 | 0.195 | |
Fe | 0.963 | −1.132 | 1.092 | −0.050 | 0.916 | −0.156 | 0.141 | −0.044 | |
Cr | 0.860 | −58.897 | 51.417 | −0.346 | 0.375 | −10.772 | 4.171 | −0.342 |
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Rył, A.; Ciosek, Ż.; Szylińska, A.; Jurewicz, A.; Bohatyrewicz, A.; Rotter, I. Concentrations of Bioelements (Zn, Cu, Fe, Cr, Mg, Mn) in Serum and Bone Tissue of Aging Men Undergoing Hip Arthroplasty: Implications for Erectile Dysfunction. Biomolecules 2024, 14, 565. https://doi.org/10.3390/biom14050565
Rył A, Ciosek Ż, Szylińska A, Jurewicz A, Bohatyrewicz A, Rotter I. Concentrations of Bioelements (Zn, Cu, Fe, Cr, Mg, Mn) in Serum and Bone Tissue of Aging Men Undergoing Hip Arthroplasty: Implications for Erectile Dysfunction. Biomolecules. 2024; 14(5):565. https://doi.org/10.3390/biom14050565
Chicago/Turabian StyleRył, Aleksandra, Żaneta Ciosek, Aleksandra Szylińska, Alina Jurewicz, Andrzej Bohatyrewicz, and Iwona Rotter. 2024. "Concentrations of Bioelements (Zn, Cu, Fe, Cr, Mg, Mn) in Serum and Bone Tissue of Aging Men Undergoing Hip Arthroplasty: Implications for Erectile Dysfunction" Biomolecules 14, no. 5: 565. https://doi.org/10.3390/biom14050565