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Plants 2013, 2(1), 57-71; doi:10.3390/plants2010057

Antioxidant Activities and Anti-Cancer Cell Proliferation Properties of Natsuhaze (Vaccinium oldhamii Miq.), Shashanbo (V. bracteatum Thunb.) and Blueberry Cultivars

1
Interdisciplinary Graduate School of Agriculture and Engineering, University of Miyazaki, Miyazaki 889-2192, Japan
2
Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2192, Japan
3
School of Agriculture, Tokai University, Kumamoto 869-1404, Japan
4
Miyazaki Prefectural Food Research and Development Center, Miyazaki 880-0303, Japan
Present address: Oita Prefectural Agriculture, Forestry and Fisheries Research Center Agricultural Research Division, Usa, Oita 872-0103, Japan.
*
Author to whom correspondence should be addressed.
Received: 11 December 2012 / Revised: 20 January 2013 / Accepted: 6 February 2013 / Published: 15 February 2013
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Abstract

Antioxidants are abundant in blueberries, and while there are many studies concerning the bioactive compound of fruit, it is only recently that the wild Vaccinium species has attracted attention for their diverse and abundant chemical components. The aim of this study was to investigate the bioactive compounds of blueberry cultivars and wild species found in Japan. Among the five extracts of the Vaccinium species, Natsuhaze (Vaccinium oldhamii Miq.) was found to be the most effective at inhibiting the growth of HL-60 human leukemia cells in vitro. Although all ethanol extracts showed a growth inhibitory effect on HL-60 cells, the degree of the effects differed among the species. The extract of Natsuhaze induced apoptotic bodies and nucleosomal DNA fragmentation in the HL-60 cells. Of the extracts tested, that of Natsuhaze contained the largest amount of total polyphenols and showed the greatest antioxidant activity, but the anthocyanin content of Natsuhaze was similar to that of rabbiteye blueberry (V. virgatum Ait.). The results showed that total polyphenols contributed to the high antioxidant activity and growth inhibitory effect on HL-60 human leukemia cells of Natsuhaze extract.
Keywords: anthocyanin; fruit; HL-60 human leukemia cells; polyphenol; Vaccinium corymbosum; V. virgatum anthocyanin; fruit; HL-60 human leukemia cells; polyphenol; Vaccinium corymbosum; V. virgatum
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Tsuda, H.; Kunitake, H.; Kawasaki-Takaki, R.; Nishiyama, K.; Yamasaki, M.; Komatsu, H.; Yukizaki, C. Antioxidant Activities and Anti-Cancer Cell Proliferation Properties of Natsuhaze (Vaccinium oldhamii Miq.), Shashanbo (V. bracteatum Thunb.) and Blueberry Cultivars. Plants 2013, 2, 57-71.

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