Next Article in Journal
Uncovering the Hidden Burden of Pharmaceutical Poisoning in High-Income and Low-Middle-Income Countries: A Scoping Review
Previous Article in Journal
The Association of Serotonin Toxicity with Combination Linezolid–Serotonergic Agent Therapy: A Systematic Review and Meta-Analysis
 
 
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Patterns of Drug Utilization and Self-Medication Practices: A Cross Sectional Study

1
Pharmacy Practice Department, College of Clinical Pharmacy, King Faisal University, Al-Ahsaa 31982, Saudi Arabia
2
Aston Medical School, College of Health and Life Sciences, Aston University, Birmingham B4 7ET, UK
3
High Institute of Public Health, Alexandria University, Alexandria 21526, Egypt
4
Pharmacy Division, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester M13 9PL, UK
*
Author to whom correspondence should be addressed.
Pharmacy 2023, 11(6), 183; https://doi.org/10.3390/pharmacy11060183
Submission received: 1 November 2023 / Revised: 12 November 2023 / Accepted: 16 November 2023 / Published: 22 November 2023

Abstract

:
Background: Self-medication (SM) is a growing phenomenon worldwide that has recently been classified as one of the most serious public health problems. SM can result in an incorrect self-diagnosis, inappropriate treatment, potential adverse reactions, interactions, and the masking of more sinister disease. Objectives: To assess the prevalence of SM practices amongst healthcare professionals and the general population in Saudi Arabia and to identify the sociodemographic contributing factors to this practice. Methods: A total of 540 participants were enrolled in this study. Participants were asked to complete the study questionnaire comprising two sections to gather demographic information and to collect data regarding SM practice. Results: The prevalence of SM practice among the study participants was 78.6%, and it was the highest among the middle age groups of (21–40 years) 82% compared to the younger and older age groups. The observed prevalence was higher in the female participants (53.7%) and those who live alone. Type of education did not affect the attitude of SM (p = 0.374); however, level of education strongly affected the prevalence of the SM, with higher incidence among university graduates (p < 0.001). Analgesics with antipyretics properties were the most self-medicated drugs. Patients considering their illnesses minor was the main reason behind the high prevalence of this practice. Among healthcare professions the highest prevalence of SM was found among pharmacists (95%), followed by physicians, nurses, and other medical practitioners. Conclusion: The general population should be better educated and made conscious about the consequences, risks, and side effects of SM. Awareness campaigns may prove to be useful in this matter, allowing the patient to consider the appropriateness of this practice. Individuals in the age group of 21–40 years, females, and those who live alone should be considered priority target populations in the design and implementation of SM awareness projects.

1. Introduction

Self-medication (SM) has gained significant importance in the healthcare sector over the past decade, with its definition constantly evolving to keep pace with the rapid changes in international drug and safety regulations [1]. The initial definition of SM, introduced by the World Health Organization (WHO), referred to the use of pharmaceutical products to address undiagnosed or self-diagnosed symptoms [2]. However, as over-the-counter medications (OTC) proliferated and direct-to-consumer advertisements (DTCA) became widespread, the definition expanded to encompass the consumption of prescribed drugs for chronic or recurrent illnesses without physician referral [3,4,5]. Later, the definition was further broadened to incorporate the utilization of herbal/traditional medicine and homemade remedies without medical supervision [6,7]. SM also encompasses patients’ choice of medication for managing a chronic or recurring condition following the initial diagnosis and prescription by a physician, as well as the act of administering medicinal products to family members, particularly infants, children, or the elderly [8].
Over the past decade, the widespread availability, accessibility, and affordability of drugs have contributed to the emergence of SM as a significant global public health issue [9,10]. Recent studies have indicated a consistent and upward trend in this practice in recent years, with estimates from various researchers suggesting that nearly 40% of individuals experiencing new medical complaints resort to non-prescribed drugs to alleviate their symptoms [11,12]. Although it is important to note that SM should be distinguished from responsible self-care, where individuals take appropriate measures for their well-being under the guidance of healthcare professionals, this rapid expansion of SM has resulted in approximately 70% of the global disease burden [13]. Moreover, SM has been directly associated with numerous critical drug-related issues, including the rise of antibiotic resistance [14], drug toxicities, misuse, abuse [15], polypharmacy [16], drug–drug interactions [17,18], and even drug-induced congenital anomalies [19]. Another key problem associated with this practice is misdiagnosis. Without proper medical assessment and diagnosis, individuals may inaccurately identify their health conditions, leading to the use of inappropriate medications. This can result in delayed or ineffective treatment, potentially exacerbating the underlying issue [20]. Moreover, SM can mask underlying medical conditions. By merely addressing the symptoms without proper diagnosis, individuals may unknowingly delay necessary medical attention, allowing potentially serious illnesses to progress unchecked [21].
The relationship between SM and the economy of countries is complex and multifaceted. Initially, it was believed that SM is primarily prevalent in economically deprived countries and developing nations, where health literacy, fewer restrictions on the sale of drugs, limited healthcare resources, and high healthcare costs can make it difficult for individuals to seek medical attention for minor health issues [22,23,24]. However, recent research has shown a significant increase in the percentage of drugs being sold and used without a prescription even in developed countries [25,26]. For instance, in Germany, it has been reported that 40% of the population engages in SM at least once a month [27]. Similarly, in Europe, the prevalence of SM ranges from 7% to 50% [28], with the highest rates observed in the less economically developed countries in northwest Europe [29,30].
Reports indicate that in the United States, approximately 40% of the population self-medicates without consulting a medical professional [31], similar patterns were reported in Finland with rates ranging from 17% to 39% [32,33], while in Indonesia, the practice has surged to as high as 90% [34]. This SM trend extends also to the gulf region, where individuals often rely on over-the-counter medications to address minor health concerns [35]. In the kingdom of Saudi Arabia (KSA), researchers have reported that as many as 81% of the general population have acknowledged using medications without a prescription at some point in their lives [35]. In addition to over-the-counter drugs, many people in the Gulf region turn to age-old folk remedies and traditional healing practices to alleviate common ailments [36]. These folk remedies often involve natural ingredients, herbal treatments, or homeopathic solutions that have been passed down through generations. The combination of over-the-counter medications and traditional folk remedies reflects the diverse and multifaceted approach to self-medication in this region. It is important to note that while some of these folk remedies may have cultural significance and can provide relief for minor ailments, their safety and effectiveness should be evaluated, and individuals should exercise caution when using them, especially for more serious health conditions.
At present, the World Health Organization (WHO) advocates for SM in cases of minor illnesses as a strategy to alleviate the growing burden on healthcare services, particularly in countries with limited resources [37]. However, the prominent barrier to promoting this practice lies in the potential misuse of medications by patients. Recognizing the significance of these concerns surrounding SM, the primary objective of this study is to investigate several aspects: the prevalence of SM practices among both healthcare professionals and the general population, the key sociodemographic factors influencing such practices, and the associated risks within the KSA.

2. Materials and Methods

2.1. Study Population

In this cross-sectional study utilizing descriptive questionnaires, participants were recruited from diverse regions across KSA, encompassing both healthcare professionals and the general population from 2017 to 2020.
A semi-structured questionnaire consisting of open- and close-ended questions was used to gather relevant information regarding the study variables. The questionnaire was divided into two sections: Section (A) focused on demographic information such as age, gender, and level of education; Section (B) included questions related to participants’ attitudes, perceptions, and practices of SM. Before starting the evaluation, participants were provided with detailed explanations of the study purpose. The questionnaires were distributed by the primary researcher who also provided clear definitions of certain terms to ensure consistency among participants for the purpose of this study as follows:
  • SM was defined as the use of any drug for self-treatment without a valid prescription or guidance from a physician;
  • A physician was defined as an individual authorized to prescribe drugs;
  • Drugs were defined as substances used for the treatment or prevention of illnesses.

2.2. Ethical Approval

The study was approved by the Research and Ethics Committee of College of Clinical Pharmacy, King Faisal University, Saudi Arabia (Pharmacy practice, 2017). An informed written consent was sought from all the study participants before conducting the study. A full right to withdraw, confidentiality, and anonymity of the data were guaranteed to all the study participants.

2.3. Data Analysis

Data analysis was performed using the Statistical Package for Social Sciences (SPSS) version 25. The results obtained from the analysis were presented in terms of counts and proportions. To compare between different study groups, the Chi-square (χ2) test was employed. Descriptive statistics were used to summarize qualitative data in terms of numbers and percentages. Statistical significance was determined by considering a p-value of less than 0.05. Any incomplete responses to the questionnaire were excluded from the final analysis to ensure data integrity. It is important to note that in certain questions, where multiple choices were allowed, the total percentage may not always add up to 100%.

3. Results

A total of 725 participant (A response rate of 72.5%) were included in the study; of them, 155 never practiced SM. The remaining 570 participants were included in the study; of them, 30 participants did not complete the questionnaire and were excluded from the final data analysis.
Of the remaining 540 participants, 55.6% (n = 300) were males and 44.4% (n = 240) were females. The mean age of the study respondents was 28 ± 0.6 years. Healthcare professionals, e.g., physicians, nurses, pharmacists, and dentists, represented 15.4% (n = 83) of the study population. A total of 69.1% of the participants (n = 373) were university graduates, while primary and high school graduates represented 30.9% (n = 167) of the population. Among the participants included in the study, a majority of 77.6% (n = 419) reported having a good health status, while 22.4% (n = 121) indicated suffering from chronic illnesses (Table 1).
SM prevalence among the whole study cohort was 78.6%, with the highest percentage (82%) being among the middle age group (21–40 years) compared to 23% and 44% in the younger and older age groups, respectively. Observed prevalence was higher in the female participants 53.7% (n = 161) compared to the males 46.2% (n = 111).
Type of education did not affect the attitude of SM practice between different groups, and no statically significant differences were found between medical and non-medical education groups (p = 0.374). However, level of education strongly affected its prevalence, with higher incidence among university graduates (p < 0.001) Table 2.
Among healthcare professions, the highest prevalence of SM was found between pharmacists (95%), followed by physicians, nurses, and other medical practitioners (≈70% in all). Study participants reported several reasons behind this practice. Considering their illness to be too trivial for consultation was the main reason in 60% of the study population (n = 324), followed by time saving and ease of availability in 34% of the population (n = 183) (Figure 1).
Most of the study cohort obtained their self-medicated drugs from private pharmacies (67%), followed by hospital pharmacies (21%), supermarkets (9%), and 3% via the internet. Fear of adverse drug reactions and inappropriate drug usage were the main reasons behind opposing this practice by the study participants.
Of the studied cohort, 109 (20.2%) experienced serious side effects from the consumed drugs. The reported adverse events of the SM drugs are listed in Table 3. More than half the study participants stated that their main source of information about the used drugs is pharmacists (52.8%, n = 285) followed by physician assistants (44.1%, n = 238). Almost a quarter of the study participants (24.3%, n = 131) used their old prescriptions for the same disease as a source for information about the drug. It was also noticed that 39.3% of the participants (n = 212) reported the internet as their main source of information (Table 3).
Painkillers were the most commonly used class of drugs in SM by the majority of the study participants (78%), followed by antibiotics (70%) and antipyretics and cough syrups (48%). Other drugs used for SM are shown in (Figure 2). The vast majority of the study participants (57.6%) (n = 311) read the package insert to acquire information about the drugs.
Among the different indications for SM reported by the participants, headache was the most common (74%) (n = 400), followed by fever (72%) (n = 389), cough/cold (59%) (n = 319), nasal congestion (39%) (n = 211), diarrhea (38%) (n = 205), muscle pain (33%) (n = 178), runny nose (30%) (n = 162), heartburn (27%) (n = 146), nausea (25%) (n = 135), allergy (21%) (114), and mouth ulcer (11%) (n = 60) (Table 4).
More than half of the participants (52.9%) reported SM as an acceptable practice, while 11% considered it unacceptable. Only 36% of the participants had a positive attitude towards SM and favored this practice.

4. Discussion

Over the past decade, SM has gained widespread recognition in healthcare systems. Extensive research has highlighted both the advantages and disadvantages of SM, depending on the individual’s knowledge about the condition being treated and the extent of the practice.
Despite the KSA’s strict regulations to control the dispensing of drugs without a prescription [38], effectively controlling SM practices has proven to be a challenge. This was attributed to the increased number of private pharmacies and the wide availability of non-prescribed and OTC medications in community pharmacies [39,40]. In accordance with these findings, the prevalence of SM in the current study was found to be 78.6%, with more than 50% of the study population identifying community pharmacies as their primary source for obtaining medications for this practice. These findings align with similar studies conducted in other Gulf countries that share similar national regulations on drug dispensing. For instance, Kuwait reported a SM prevalence of 92% [41], while the United Arab Emirates reported a prevalence of 89% [42]. These findings underscore the significance of SM practices in the region, highlighting the need for effective measures to ensure the safe and responsible use of medications.
Our analysis has also indicated that the highest prevalence of SM is observed among young adults, specifically those aged between 21 and 40 years. These findings align with previous studies, highlighting a higher prevalence of drug misuse and abuse within this age group, primarily due to their limited health literacy and awareness of their own health needs [43,44]. To delve deeper, we recommend exploring the factors contributing to this practice in this age group. This may include factors such as peer pressure, stress, mental health issues, and societal norms. Additionally, economic instability and access to substances can be significant drivers [45,46]. Highlighting the significance of effective health education is also essential in order to elaborate on how it can result in suboptimal decision-making regarding SM. Young adults, due to their limited health knowledge, may not grasp the full extent of the health hazards linked to medications misuse, rendering them more susceptible to engaging in unsafe behaviors [45]. Investigating the interconnections among various factors that promote SM is a valuable step in formulating strategies aimed at mitigating health risks related to drug use among adolescents. Furthermore, these insights can play a pivotal role in raising awareness among adolescents about the potential dangers associated with uninformed and unconsulted drug usage.
Among the various drugs consumed by the study participants, analgesics with antipyretic properties were found to be the most commonly used. This observation aligns with the fact that headache and fever were reported as the most prevalent indications for self-treatment in this cohort. Next, and despite the Saudi adaptation of the WHO antimicrobial resistance global action plan, which aims to increase awareness regarding the misuse of antibiotics in the Kingdom [47], a concerning 70% of the study population reported using antibiotics without a physician’s recommendation. Moreover, among these individuals, 66.9% used antibiotics for a duration of 2 days, while 30.1% admitted to using them for more than 20 days without a proper diagnosis. This practice has the potential to contribute to the spread of multidrug-resistant organisms within the community and is consistent with studies examining antibiotic use among outpatients and the general population in the Kingdom [48,49]. In line with this, international health surveys that have identified Saudi Arabia as having the highest prevalence of multidrug-resistant gram-positive bacteria in the Gulf region [50], which poses a significant public health concern, as the effectiveness of antibiotics in treating bacterial infections diminishes when resistance emerges.
A significant majority of the study population identified pharmacists as their primary source for obtaining misused antimicrobials. These findings are consistent with other studies that have reported 80% of community pharmacists in the Kingdom dispensing antibiotics without prescriptions, with only 1% of pharmacists refusing to sell antibiotics over the counter [51,52]. These alarming results emphasize the immediate need to implement stricter regulations within the healthcare system to prohibit the supply of drugs without prescriptions from community pharmacies. Furthermore, our study revealed that pharmacy clerks and physician assistants were perceived as the easiest way to obtain rapid diagnoses and information about self-medicated drugs. This, again, underscores a significant gap in prescribing and consultation regulations within the Kingdom, emphasizing the importance of introducing non-medical prescribing training for non-medical practitioners. Expanding the prescribing rights to qualified healthcare professionals other than physicians can improve patient care by increasing the availability of qualified healthcare providers. Simultaneously, it would provide patients with faster access to necessary medicines and healthcare services, which was highlighted as a main reason behind SM practices in 34% of our study population.
In many countries, including the United Kingdom (UK) and Scotland, non-medical prescribing has gained considerable traction. It encompasses several healthcare professions, such as nurse prescribers, pharmacist prescribers, and allied health professionals. This model has been pivotal in alleviating the burden on general practitioners, enhancing patient access, and ensuring that individuals receive timely and appropriate treatment from professionals with specialized knowledge. The UK model serves as an exemplary case study for the successful implementation of non-medical prescribing [53,54]. Similarly, in Canada, pharmacists have gained prescribing privileges in some provinces. This model empowers pharmacists to assess and prescribe certain medications, allowing patients to receive immediate advice and treatment for common health conditions. It has been particularly useful in improving access to primary care, especially in underserved areas [55]. We also believe that promoting non-medical prescribing in KSA will be a potential strategy to curb SM practices, given that 34% of our study cohort identified the allure of reducing costs as a significant factor in their decision-making.
Consistent with findings in the literature [56,57], our study revealed a high prevalence of SM among female participants. While some researchers have attributed this phenomenon to physiological factors such as dysmenorrhea or menstrual-associated symptoms, our study observed a higher SM prevalence among women even after adjusting for confounding variables, including chronic and acute disorders.
This higher tendency towards self-care among adult females, as reported by some authors, may reflect their proactive approach to managing their health [58]. However, we believe that cultural factors can also play a significant role; this increased knowledge of drugs and self-care may be a result of cultural norms that encourage them to care for themselves and seek remedies independently [59]. In addition and contrary to the strong evidence linking SM practice to the presence of medications stored at home by family members [58], our findings revealed a higher prevalence of the practice among single individuals. However, this discrepancy can be explained by the greater sense of personal autonomy observed in this group, leading to a lower inclination to seek professional healthcare assistance.
Our study also revealed a positive correlation between education level and the prevalence of SM, which is consistent with findings from existing literature [60,61,62]. These findings support the cultural belief in society that non-medical individuals can acquire knowledge on the proper use of medications, often through learning from older family members or family counsellors. Interestingly, the type of education did not have any significant influence on SM prevalence. Participants with medical education, in particular, did not endorse this practice, attributing their knowledge to a heightened awareness of the adverse effects and toxicities associated with medications. These findings suggest that while education can play a role in increasing the prevalence of SM, it is not solely determined by the type of education received.
Socioeconomic status was one of the main highlighted contributors to increased SM in the literature; low income and low standards of living were reported to be positively associated with increased tendency to self-medicate in many countries [60,61,62]. However, contrary to these findings, our study revealed that higher standards of living and income were directly associated with increased SM practices. On the other hand, self-limiting minor illnesses and time saving were the main reasons behind SM in our cohort; they were also reported as the most prevalent indication for SM in many other studies where “low disease severity” was reported as the main cause followed by the belief that a verbal consultation with a doctor sufficed [63]. This also goes well with our findings wherein participants with a previous illness were more likely to practice SM using remaining medications from other illnesses they suffered from.
While direct-to-consumer advertising (DTCA) of prescription drugs is prohibited in Saudi Arabia and typically directed towards healthcare professionals, the Saudi Food and Drug Authority (SFDA) permits the promotion of OTC drugs directly to the general public. Our study revealed a positive association between DTCPA and SM practices. This finding raises concerns about the regulatory measures surrounding DTCPA, as critics argue that the current rules imposed by the FDA may be too lenient and insufficiently enforced.
DTCPA provides information about medications directly from the drug manufacturers, but it is important to acknowledge that this source of information is susceptible to bias and significant conflicts of interest [64]. The inherent commercial nature of DTCPA raises questions about the accuracy and objectivity of the information provided, potentially leading to incorrect treatment decisions and their subsequent consequences.
Given the potential risks associated with DTCPA, there is a need for stronger regulations and more robust enforcement mechanisms to ensure the integrity and reliability of the information being disseminated to the general public. This includes addressing the issue of bias and conflicts of interest that may arise from the direct involvement of drug manufacturers in promoting their products to consumers.
This study acknowledges several limitations that should be taken into consideration. First, we did not account for the use of medications obtained from the black market, i.e., pharmaceutical substances and prescription medications that are bought, sold, or traded illegally by individuals or electronic platforms. Sharing and secondary distribution from friends and family could also impact the prevalence and patterns of SM. Additionally, as a cross-sectional study, it is important to acknowledge the limitations in establishing causal relationships between variables, as the temporal sequence of events cannot be definitively determined. Therefore, future longitudinal studies are recommended in order to provide a more robust understanding of these relationships.
In conclusion, the alarmingly high prevalence of SM in this study calls for immediate attention. The general population should be better educated and made conscious of the consequences, risks, and side effects of SM. Awareness campaigns may prove to be useful in this matter, allowing the patient to consider the appropriateness of this practice. Individuals in the age group of 21–40 years, females, and those who live alone should be considered priority target populations in the design and implementation of SM awareness projects. Overall, this study provides valuable information that can guide health authorities in combating the widespread practice of SM. Through concerted efforts in regulatory control, it is possible to work towards promoting responsible medication practices and ensuring the well-being of individuals in the Saudi community.

Author Contributions

Conceptualization, H.S.; methodology, H.S.; validation, H.S. and M.M.; formal analysis, H.A.-O. and M.M.; investigation, H.A.-O.; resources, H.S.; data curation, H.S. and H.A.-O.; writing—original draft preparation, H.S., H.A.-O. and M.K.M.; writing—review and editing, H.S., R.A.-W. and M.K.M.; visualization, H.A.-O. and R.A.-W.; supervision, H.S.; project administration, H.S. All authors have read and agreed to the published version of the manuscript.

Funding

This research received no external funding.

Institutional Review Board Statement

The study was conducted in accordance with the Declaration of Helsinki and approved by the Institutional Review Board of the Collage of Clinical Pharmacy, King Faisal University.

Informed Consent Statement

Informed consent was obtained from all subjects involved in the study.

Data Availability Statement

Data are contained within the article.

Conflicts of Interest

The authors declare no conflict of interest.

References

  1. Khantzian, E.J. Commentary: It Is Not About Supply, It Is About Demand: Why the Self-Medication Hypotheses Is Still So Important. Am. J. Addict. 2021, 30, 301–304. [Google Scholar] [CrossRef]
  2. Bennadi, D. Self-Medication: A Current Challenge. J. Basic Clin. Pharm. 2013, 5, 19–23. [Google Scholar] [CrossRef]
  3. Khalil Zadeh, N.; Robertson, K.; Green, J.A. ‘At-Risk’ Individuals’ Responses to Direct to Consumer Advertising of Prescription Drugs: A Nationally Representative Cross-Sectional Study. BMJ Open 2017, 7. [Google Scholar] [CrossRef]
  4. Ball, J.G.; Manika, D.; Stout, P. Causes and Consequences of Trust in Direct-to-Consumer Prescription Drug Advertising. Int. J. Advert. 2016, 35, 216–247. [Google Scholar] [CrossRef]
  5. Sullivan, H.W.; Aikin, K.J.; Berktold, J.; Stein, K.L.; Hoverman, V.J. Direct-to-Consumer Prescription Drug Advertising and Patient-Provider Interactions. J. Am. Board Fam. Med. 2020, 33, 279–283. [Google Scholar] [CrossRef]
  6. Marathe, P.A.; Kamat, S.K.; Tripathi, R.K.; Raut, S.B.; Khatri, N.P. Over-the-Counter Medicines: Global Perspective and Indian Scenario. J. Postgrad. Med. 2020, 66, 28. [Google Scholar]
  7. Rashrash, M.; Schommer, J.C.; Brown, L.M. Prevalence and Predictors of Herbal Medicine Use Among Adults in the United States. J. Patient Exp. 2017, 4, 108–113. [Google Scholar] [CrossRef]
  8. World Health Organization. Guidelines for the Regulatory Assessment of Medicinal Products for Use in Self-Medication; World Health Organization: Geneva, Switzerland, 2002.
  9. McCabe, S.E.; West, B.T.; Teter, C.J.; Boyd, C.J. Trends in Medical Use, Diversion, and Nonmedical Use of Prescription Medications among College Students from 2003 to 2013: Connecting the Dots. Addict. Behav. 2014, 39, 1176–1182. [Google Scholar] [CrossRef]
  10. Onchonga, D.; Omwoyo, J.; Nyamamba, D. Assessing the Prevalence of Self-Medication among Healthcare Workers before and during the 2019 SARS-CoV-2 (COVID-19) Pandemic in Kenya. Saudi Pharm. J. 2020, 28, 1149–1154. [Google Scholar] [CrossRef]
  11. Jerez-Roig, J.; Medeiros, L.F.B.; Silva, V.A.B.; Bezerra, C.L.P.A.M.; Cavalcante, L.A.R.; Piuvezam, G.; Souza, D.L.B. Prevalence of Self-Medication and Associated Factors in an Elderly Population: A Systematic Review. Drugs Aging 2014, 31, 883–896. [Google Scholar] [CrossRef]
  12. Alshogran, O.Y.; Alzoubi, K.H.; Khabour, O.F.; Farah, S. Patterns of Self-Medication among Medical and Nonmedical University Students in Jordan. Risk Manag. Healthc. Policy 2018, 11, 169–176. [Google Scholar] [CrossRef]
  13. Karimy, M.; Rezaee-Momtaz, M.; Tavousi, M.; Montazeri, A.; Araban, M. Risk Factors Associated with Self-Medication among Women in Iran. BMC Public Health 2019, 19, 1033. [Google Scholar] [CrossRef]
  14. Zeb, S.; Mushtaq, M.; Ahmad, M.; Saleem, W.; Rabaan, A.A.; Naqvi, B.S.Z.; Garout, M.; Aljeldah, M.; Al Shammari, B.R.; Al Faraj, N.J.; et al. Self-Medication as an Important Risk Factor for Antibiotic Resistance: A Multi-Institutional Survey among Students. Antibiotics 2022, 11, 842. [Google Scholar] [CrossRef]
  15. Hughes, G.F.; McElnay, J.C.; Hughes, C.M.; McKenna, P. Abuse/Misuse of Non-Prescription Drugs. Pharm. World Sci. 1999, 21, 251–255. [Google Scholar] [CrossRef]
  16. Ruiz, M. Risks of Self-Medication Practices. Curr. Drug Saf. 2010, 5, 315–323. [Google Scholar] [CrossRef]
  17. Sihvo, S.; Klaukka, T.; Martikainen, J.; Hemminki, E. Frequency of Daily Over-the-Counter Drug Use and Potential Clinically Significant over-the-Counter-Prescription Drug Interactions in the Finnish Adult Population. Eur. J. Clin. Pharmacol. 2000, 56, 495–499. [Google Scholar] [CrossRef]
  18. Qato, D.M.; Wilder, J.; Schumm, L.P.; Gillet, V.; Alexander, G.C. Changes in Prescription and Over-the-Counter Medication and Dietary Supplement Use among Older Adults in the United States, 2005 vs. 2011. JAMA Intern. Med. 2016, 176, 473–482. [Google Scholar] [CrossRef]
  19. Marwa, K.J.; Njalika, A.; Ruganuza, D.; Katabalo, D.; Kamugisha, E. Self-Medication among Pregnant Women Attending Antenatal Clinic at Makongoro Health Centre in Mwanza, Tanzania: A Challenge to Health Systems. BMC Pregnancy Childbirth 2018, 18, 16. [Google Scholar] [CrossRef]
  20. Bradley, C.P.; Bond, C. Increasing the Number of Drugs Available over the Counter: Arguments for and Against. Br. J. Gen. Pract. 1995, 45, 553–556. [Google Scholar]
  21. Gualano, M.R.; Bert, F.; Passi, S.; Stillo, M.; Galis, V.; Manzoli, L.; Siliquini, R. Use of Self-Medication among Adolescents: A Systematic Review and Meta-Analysis. Eur. J. Public Health 2015, 25, 444–450. [Google Scholar] [CrossRef]
  22. Nepal, G.; Bhatta, S. Self-Medication with Antibiotics in WHO Southeast Asian Region: A Systematic Review. Cureus 2018, 10, e2428. [Google Scholar] [CrossRef]
  23. Alhomoud, F.; Aljamea, Z.; Almahasnah, R.; Alkhalifah, K.; Basalelah, L.; Alhomoud, F.K. Self-Medication and Self-Prescription with Antibiotics in the Middle East—Do They Really Happen? A Systematic Review of the Prevalence, Possible Reasons, and Outcomes. Int. J. Infect. Dis. 2017, 57, 3–12. [Google Scholar] [CrossRef]
  24. Khalifeh, M.M.; Moore, N.D.; Salameh, P.R. Self-Medication Misuse in the Middle East: A Systematic Literature Review. Pharmacol. Res. Perspect. 2017, 5, e00323. [Google Scholar] [CrossRef]
  25. Davies, A.; Green, M.A.; Singleton, A.D. Using Machine Learning to Investigate Self-Medication Purchasing in England via High Street Retailer Loyalty Card Data. PLoS ONE 2018, 13, e0207523. [Google Scholar] [CrossRef]
  26. Rahmawati, R.; Bajorek, B.V. Self-Medication among People Living with Hypertension: A Review. Fam. Pract. 2017, 34, 147–153. [Google Scholar] [CrossRef]
  27. Italia, S.; Brand, H.; Heinrich, J.; Berdel, D.; von Berg, A.; Wolfenstetter, S.B. Utilization of Self-Medication and Prescription Drugs among 15-Year-Old Children from the German GINIplus Birth Cohort. Pharmacoepidemiol. Drug Saf. 2015, 24, 1133–1143. [Google Scholar] [CrossRef]
  28. Grigoryan, L.; Haaijer-Ruskamp, F.M.; Burgerhof, J.G.M.; Mechtler, R.; Deschepper, R.; Tambic-Andrasevic, A.; Andrajati, R.; Monnet, D.L.; Cunney, R.; Di Matteo, A.; et al. Self-Medication with Antimicrobial Drugs in Europe. Emerg. Infect. Dis. 2006, 12, 452. [Google Scholar] [CrossRef]
  29. Zarb, P.; Goossens, H. European Surveillance of Antimicrobial Consumption (ESAC): Value of a Point-Prevalence Survey of Antimicrobial Use across Europe. Drugs 2011, 71, 745–755. [Google Scholar] [CrossRef]
  30. Grigoryan, L.; Monnet, D.; Haaijer-Ruskamp, F.; Bonten, M.; Lundborg, S.; Verheij, T. Self-Medication with Antibiotics in Europe: A Case for Action. Curr. Drug Saf. 2010, 5, 329–332. [Google Scholar] [CrossRef]
  31. Combest, W.; Newton, M.; Combest, A.; Kosier, J.H. Effects of Herbal Supplements on the Kidney. Urol. Nurs. Off. J. Am. Urol. Assoc. Allied 2005, 25, 381–386. [Google Scholar]
  32. Ylinen, S.; Hämeen-Anttila, K.; Sepponen, K.; Lindblad, A.K.; Ahonen, R. The Use of Prescription Medicines and Self-Medication among Children-a Population-Based Study in Finlandy. Pharmacoepidemiol. Drug Saf. 2010, 19, 1000–1008. [Google Scholar] [CrossRef]
  33. Hämeen-Anttila, K.; Lindell-Osuagwu, L.; Sepponen, K.; Vainio, K.; Halonen, P.; Ahonen, R. Factors Associated with Medicine Use among Children Aged under 12 Years—A Population Survey in Finland. Pharmacoepidemiol. Drug Saf. 2010, 19, 400–407. [Google Scholar] [CrossRef]
  34. Brata, C.; Fisher, C.; Marjadi, B.; Schneider, C.R.; Clifford, R.M. Factors Influencing the Current Practice of Self-Medication Consultations in Eastern Indonesian Community Pharmacies: A Qualitative Study. BMC Health Serv. Res. 2016, 16, 179. [Google Scholar] [CrossRef]
  35. Al-Ghamdi, S.; Alfauri, T.M.; Alharbi, M.A.; Alsaihati, M.M.; Alshaykh, M.M.; Alharbi, A.A.; Aljaizani, N.S.; Allehiby, I.A.; Alzahrani, M.A.; Alharbi, A.S. Current Self-Medication Practices in the Kingdom of Saudi Arabia: An Observational Study. Pan Afr. Med. J. 2020, 37, 51. [Google Scholar] [CrossRef]
  36. Alkhamaiseh, S.I.; Aljofan, M. Prevalence of Use and Reported Side Effects of Herbal Medicine among Adults in Saudi Arabia. Complement. Ther. Med. 2020, 48, 102255. [Google Scholar] [CrossRef]
  37. Galato, D.; Galafassi, L.D.M.; Alano, G.M.; Trauthman, S.C. Responsible Self-Medication: Review of the Process of Pharmaceutical Attendance. Braz. J. Pharm. Sci. 2009, 45, 625–633. [Google Scholar] [CrossRef]
  38. Alrasheedy, A.A.; Alsalloum, M.A.; Almuqbil, F.A.; Almuzaini, M.A.; Aba Alkhayl, B.S.; Albishri, A.S.; Alharbi, F.F.; Alharbi, S.R.; Alodhayb, A.K.; Alfadl, A.A.; et al. The Impact of Law Enforcement on Dispensing Antibiotics without Prescription: A Multi-Methods Study from Saudi Arabia. Expert Rev. Anti-Infect. Ther. 2019, 18, 87–97. [Google Scholar] [CrossRef]
  39. Al-Mohamadi, A.; Badr, A.; Bin Mahfouz, L.; Samargandi, D.; Al Ahdal, A. Dispensing Medications without Prescription at Saudi Community Pharmacy: Extent and Perception. Saudi Pharm. J. 2013, 21, 13–18. [Google Scholar] [CrossRef]
  40. Al-Jedai, A.; Qaisi, S.; Al-Meman, A. Pharmacy Practice and the Health Care System in Saudi Arabia. Can. J. Hosp. Pharm. 2016, 69, 231. [Google Scholar] [CrossRef]
  41. Abahussain, E.; Matowe, L.K.; Nicholls, P.J. Self-Reported Medication Use among Adolescents in Kuwait. Med. Princ. Pract. 2005, 14, 161–164. [Google Scholar] [CrossRef]
  42. Shehnaz, S.I.; Khan, N.; Sreedharan, J.; Arifulla, M. Drug Knowledge of Expatriate Adolescents in the United Arab Emirates and Their Attitudes towards Self-Medication. Int. J. Adolesc. Med. Health 2014, 26, 423–431. [Google Scholar] [CrossRef]
  43. Lee, C.H.; Chang, F.C.; Hsu, S.D.; Chi, H.Y.; Huang, L.J.; Yeh, M.K. Inappropriate Self-Medication among Adolescents and Its Association with Lower Medication Literacy and Substance Use. PLoS ONE 2017, 12, e0189199. [Google Scholar] [CrossRef]
  44. Wang, T.C.; Chang, F.C.; Lee, C.H.; Chi, H.Y.; Huang, L.J.; Tseng, C.C. Adolescents’ Misperceptions and Low Literacy Associated with the Inappropriate Use of over-the-Counter Cold Medicines. J. Subst. Use 2020, 25, 101–106. [Google Scholar] [CrossRef]
  45. Shehnaz, S.I.; Agarwal, A.K.; Khan, N. A Systematic Review of Self-Medication Practices Among Adolescents. J. Adolesc. Health 2014, 55, 467–483. [Google Scholar] [CrossRef]
  46. World Health Organization. Prevalence of Self-Medication in University Students: Systematic Review and Meta-Analysis. Available online: http://www.emro.who.int/emhj-volume-26-2020/volume-26-issue-7/prevalence-of-self-medication-in-university-students-systematic-review-and-meta-analysis.html (accessed on 12 November 2023).
  47. World Health Organization. Global Action Plan on Antimicrobial Resistance. Microbe Mag. 2015. [Google Scholar] [CrossRef]
  48. Al Rasheed, A.; Yagoub, U.; Alkhashan, H.; Abdelhay, O.; Alawwad, A.; Al Aboud, A.; Al Battal, S. Prevalence and Predictors of Self-Medication with Antibiotics in Al Wazarat Health Center, Riyadh City, KSA. BioMed Res. Int. 2016, 2016, 3916874. [Google Scholar] [CrossRef]
  49. El Zowalaty, M.E.; Belkina, T.; Bahashwan, S.A.; El Zowalaty, A.E.; Tebbens, J.D.; Abdel-Salam, H.A.; Khalil, A.I.; Daghriry, S.I.; Gahtani, M.A.; Madkhaly, F.M.; et al. Knowledge, Awareness, and Attitudes toward Antibiotic Use and Antimicrobial Resistance among Saudi Population. Int. J. Clin. Pharm. 2016, 38, 1261–1268. [Google Scholar] [CrossRef]
  50. Aly, M.; Balkhy, H.H. The Prevalence of Antimicrobial Resistance in Clinical Isolates from Gulf Corporation Council Countries. Antimicrob. Resist. Infect. Control 2012, 1, 26. [Google Scholar] [CrossRef]
  51. Bin Abdulhak, A.A.; Altannir, M.A.; Almansor, M.A.; Almohaya, M.S.; Onazi, A.S.; Marei, M.A.; Aldossary, O.F.; Obeidat, S.A.; Obeidat, M.A.; Riaz, M.S.; et al. Non Prescribed Sale of Antibiotics in Riyadh, Saudi Arabia: A Cross Sectional Study. BioMed Cent. 2011, 11, 538. [Google Scholar] [CrossRef]
  52. Zowawi, H.M.; Balkhy, H.H.; Walsh, T.R.; Paterson, D.L. β-Lactamase Production in Key Gram-Negative Pathogen Isolates from the Arabian Peninsula. Clin. Microbiol. Rev. 2013, 26, 361–380. [Google Scholar] [CrossRef]
  53. Non-Medical Prescribing in Primary Care in the United Kingdom: An Overview of the Current Literature|Journal of Prescribing Practice. Available online: https://www.magonlinelibrary.com/doi/full/10.12968/jprp.2021.3.9.352 (accessed on 7 November 2023).
  54. Graham-Clarke, E.; Rushton, A.; Noblet, T.; Marriott, J. Non-Medical Prescribing in the United Kingdom National Health Service: A Systematic Policy Review. PLoS ONE 2019, 14, e0214630. [Google Scholar] [CrossRef]
  55. Yuksel, N.; Eberhart, G.; Bungard, T.J. Prescribing by Pharmacists in Alberta. Am. J. Health-Syst. Pharm. 2008, 65, 2126–2132. [Google Scholar] [CrossRef]
  56. Jafari, F.; Khatony, A.; Rahmani, E. Prevalence of Self-Medication among the Elderly in Kermanshah-Iran. Glob. J. Health Sci. 2015, 7, 360. [Google Scholar] [CrossRef]
  57. Carrasco-Garrido, P.; Hernández-Barrera, V.; López De Andrés, A.; Jiménez-Trujillo, I.; Jiménez-García, R. Sex-Differences on Self-Medication in Spain. Pharmacoepidemiol. Drug Saf. 2010, 19, 1293–1299. [Google Scholar] [CrossRef]
  58. Figueiras, A.; Caamano, F.; Gestal-Otero, J.J. Sociodemographic Factors Related to Self-Medication in Spain. Eur. J. Epidemiol. 2000, 16, 19–26. [Google Scholar] [CrossRef]
  59. Alanazy, W.; Brown, A. Individual and Healthcare System Factors Influencing Antenatal Care Attendance in Saudi Arabia. BMC Health Serv. Res. 2020, 20, 49. [Google Scholar] [CrossRef]
  60. Awad, A.; Eltayeb, I.; Matowe, L.; Thalib, L. Self-Medication with Antibiotics and Antimalarials in the Community of Khartoum State, Sudan. J. Pharm. Pharm. 2005, 8, 326–331. [Google Scholar]
  61. Parimi, N.; Pinto Pereira, L.M.; Prabhakar, P. Caregivers’ Practices, Knowledge and Beliefs of Antibiotics in Paediatric Upper Respiratorytract Infections in Trinidad and Tobago: A Cross-Sectional Study. BMC Fam. Pract. 2004, 5, 28. [Google Scholar] [CrossRef]
  62. Mainous, A.G.; Cheng, A.Y.; Garr, R.C.; Tilley, B.C.; Everett, C.J.; McKee, M.D. Nonprescribed Antimicrobial Drugs in Latino Community, South Carolina. Emerg. Infect. Dis. 2005, 11, 883. [Google Scholar] [CrossRef]
  63. Limaye, D.; Limaye, V.; Krause, G.; Fortwengel, G. A Systematic Review of the Literature on Survey Questionnaires to Assess Self-Medication Practices. Int. J. Community Med. Public Health 2017, 4, 2620–2631. [Google Scholar] [CrossRef]
  64. Ventola, C.L. Direct-to-Consumer Pharmaceutical Advertising. Pharm. Ther. 2011, 36, 669–684. [Google Scholar]
Figure 1. Reasons behind self-medication as reported by the study participants. Data are presented in the form of percentages.
Figure 1. Reasons behind self-medication as reported by the study participants. Data are presented in the form of percentages.
Pharmacy 11 00183 g001
Figure 2. Categories of commonly used drugs in self-medication. Data are presented in the form of percentages (the total percentage is more than 100% as multiple choices were allowed).
Figure 2. Categories of commonly used drugs in self-medication. Data are presented in the form of percentages (the total percentage is more than 100% as multiple choices were allowed).
Pharmacy 11 00183 g002
Table 1. Distribution of the study participants according to demographic data.
Table 1. Distribution of the study participants according to demographic data.
Self-Medicating Participants
(n = 540)
Percentage (%)
Age
18–206512.0
21–3026148.3
31–4014426.7
41–505510.2
>50152.8
Sex
Male30055.6
Female24044.4
Education
Primary school50.93
High school16230.0
University35966.5
Master or PhD142.6
Type of Education
Non health education45784.6
Health education8315.4
Health status
No chronic illnesses41977.6
Chronic Illness12122.4
Table 2. Relation between education level and self-medication practice.
Table 2. Relation between education level and self-medication practice.
Education Levelχ2p
Primary/High School
(n = 167)
University Graduates
(n = 373)
No.%No.%
How many times in the past year did you treat yourself?
I cannot remember127.261.634.675 *<0.001 *
No5331.76918.5
195.43910.5
2137.86718.0
32515.04010.7
>45532.915240.8
Type of Educationχ2p
Non health education
(n = 457)
Health education
(n = 83)
No.%No.%
How many times in the past year did you treat yourself?
I cannot remember163.522.45.3560.374
No10923.81315.7
1419.078.4
27015.31012.0
35211.41315.7
>416937.03845.8
χ2: Chi square test. *: Statistically significant at p ≤ 0.05.
Table 3. Main side effects experienced by the study participants and sources of information.
Table 3. Main side effects experienced by the study participants and sources of information.
Main Side Effects
NumberPercentage with respect to total population (n = 540)Percentage with respect to individuals experienced SE (n = 109) *
GI Upset509.2645.9
Allergy478.743.1
Palpitation417.637.6
Headache183.316.5
Rash173.215.6
Dizziness163.014.7
Sources of information as reported by the study participants
Number
(n = 540)
Percentage with respect to total population *
Pharmacist28552.8
Family23844.1
Internet21239.3
Leaflet16430.4
Friends13825.6
Old prescription13124.3
Book5910.9
Advertisement254.6
* Total percentage is more than 100% as multiple choices were allowed.
Table 4. Distribution of participants according to source of information.
Table 4. Distribution of participants according to source of information.
Medical ConditionsNumber
(n = 540)
Percentage (%) with Respect to Total Population *
Headache40074
Fever38972
Cough/Cold31959
Nasal congestion21139
Diarrhea/Constipation20538
Muscle pain17833
Runny nose16230
Heartburn/Indigestion14627
Nausea13525
Allergy11421
Vomiting8716
Mouth Ulcer6011
* Total percentage is more than 100% as multiple choices were allowed.
Disclaimer/Publisher’s Note: The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content.

Share and Cite

MDPI and ACS Style

Al-Omrani, H.; Marwah, M.K.; Al-Whaib, R.; Mekkawy, M.; Shokr, H. Patterns of Drug Utilization and Self-Medication Practices: A Cross Sectional Study. Pharmacy 2023, 11, 183. https://doi.org/10.3390/pharmacy11060183

AMA Style

Al-Omrani H, Marwah MK, Al-Whaib R, Mekkawy M, Shokr H. Patterns of Drug Utilization and Self-Medication Practices: A Cross Sectional Study. Pharmacy. 2023; 11(6):183. https://doi.org/10.3390/pharmacy11060183

Chicago/Turabian Style

Al-Omrani, Hamod, Mandeep Kaur Marwah, Razan Al-Whaib, Mohammed Mekkawy, and Hala Shokr. 2023. "Patterns of Drug Utilization and Self-Medication Practices: A Cross Sectional Study" Pharmacy 11, no. 6: 183. https://doi.org/10.3390/pharmacy11060183

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop