Immune Analysis Using Vitreous Optical Coherence Tomography Imaging in Rats with Steroid-Induced Glaucoma
Abstract
1. Introduction
2. Materials and Methods
2.1. Data Collection
2.2. Image Analysis
2.3. Statistical Analysis
3. Results
3.1. Microsphere Characterisation
3.2. Ophthalmological Analysis
3.3. Computational Analysis
3.3.1. VIT/RPE Intensity
3.3.2. Correlation Analysis
3.3.3. In Vivo Analysis of Vitreous Immunity
Percentage of Opacities/Cells by Size
Average Eccentricity of the Opacities/Cells
Mean Intensity of Opacities/Cells
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Right Eye | Left Eye | |||||
---|---|---|---|---|---|---|
MsDx | MsDxF | HC | MsDx | MsDxF | HC | |
IOP/IOP | 4 w/6 w(m) | 6 w/12 w (m) | 4 w/8 w (r = 0.934, p = 0.020) | 2 w/18 w (im) | 2 w/4 w (m) 4 w/6-8-24 w (m) | |
IOP/OCT | 2 w/24 w (r = 0.988, p = 0.002) 4 w/24 w (r = 0.896, p = 0.040) | 18 w/24 w (r = 0.854, p = 0.031) | 4 w/18 w (r = 0.889, p = 0.043) | 0 w/8 w (r = 0.882, p = 0.020) 0 w/12 w (r = −0.851, p = 0.032) 6 w/8 w (r = 0.813, p = 0.049) | 24 w/24 w (im) |
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Rodrigo, M.J.; Subías, M.; Montolío, A.; Martínez-Rincón, T.; Aragón-Navas, A.; Bravo-Osuna, I.; Pablo, L.E.; Cegoñino, J.; Herrero-Vanrell, R.; Garcia-Martin, E.; et al. Immune Analysis Using Vitreous Optical Coherence Tomography Imaging in Rats with Steroid-Induced Glaucoma. Biomedicines 2024, 12, 633. https://doi.org/10.3390/biomedicines12030633
Rodrigo MJ, Subías M, Montolío A, Martínez-Rincón T, Aragón-Navas A, Bravo-Osuna I, Pablo LE, Cegoñino J, Herrero-Vanrell R, Garcia-Martin E, et al. Immune Analysis Using Vitreous Optical Coherence Tomography Imaging in Rats with Steroid-Induced Glaucoma. Biomedicines. 2024; 12(3):633. https://doi.org/10.3390/biomedicines12030633
Chicago/Turabian StyleRodrigo, Maria J., Manuel Subías, Alberto Montolío, Teresa Martínez-Rincón, Alba Aragón-Navas, Irene Bravo-Osuna, Luis E. Pablo, Jose Cegoñino, Rocío Herrero-Vanrell, Elena Garcia-Martin, and et al. 2024. "Immune Analysis Using Vitreous Optical Coherence Tomography Imaging in Rats with Steroid-Induced Glaucoma" Biomedicines 12, no. 3: 633. https://doi.org/10.3390/biomedicines12030633