Efficacy of Office-Based Salivary Ductal Steroid Irrigation for Managing Post-Irradiation Xerostomia in Head and Neck Cancer Patients: A Retrospective Study
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Population and Design
2.2. Salivary Gland Ductal Irrigation
2.3. Definition of Responsive and Non-Responsive
2.4. Statistical Analysis
3. Results
3.1. Patient Characteristics and Treatment Response
3.2. Factors Associated with Treatment Responsiveness
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Patient Group | ||||||
---|---|---|---|---|---|---|
NPC (N = 103) | Non-NPC HN Cancer (N = 32) | Sicca Syndrome (N = 12) | ||||
Age (years) 1 | 47.5 ± 9.9 | 58.0 ± 9.7 | 60.1 ± 13.7 | |||
Gender (M:F) 2 | 65:38 | 23:9 | 2:10 | |||
Number of patients per stage | ||||||
Stage I | 7 | 1 | ||||
Stage II | 17 | 2 | ||||
Stage III | 34 | 6 | ||||
Stage IV | 17 | 10 | ||||
NPC | Non-NPC HN Cancer | Sicca Syndrome | ||||
Responsive | Non-Responsive | Responsive | Non-Responsive | Responsive | Non-Responsive | |
Number of patients | 77 | 26 | 21 | 11 | 6 | 6 |
Number of irrigation treatments | 3.6 ± 1.0 | 1.2 ± 0.5 | 3.8 ± 0.9 | 1.0 ± 0.0 | 3.3 ± 1.0 | 1.0 ± 0.0 |
Stage I | 3.3 ± 0.8 | 1 | NA | NA | ||
Stage II | 4.1 ± 0.9 | 1 | NA | NA | ||
Stage III | 3.4 ± 1.0 | 1.3 ± 0.5 | 4.3 ± 1.7 | 1.0 ± 0.0 | ||
Stage IV | 3.6 ± 1.0 | 1 | 3.6 ± 0.5 | NA | ||
Interval of irrigation treatments (week) | 6.2 | 4.9 | 4.4 |
Amylase 1 a | Amylase 2 a | Paired t Test | Independent t Test | ||||||
---|---|---|---|---|---|---|---|---|---|
t Value | df | Sig (two-Tailed) | t Value | df | Sig (Two-Tailed) | ||||
Total | |||||||||
Responsive (N = 35) | 11,048 ± 1412 | 13,213 ± 2479 | −0.94 | 34 | 0.353 | 1.42 ± 0.19 | 1.17 | 38 | 0.25 |
Nonresponsive (N = 5) | 10,713 ± 3452 | 6175 ± 1670 | 1.82 | 4 | 0.143 | 0.84 ± 0.22 | |||
Amylase 1 a | Amylase 2 a | Paired t Test | Independent t Test | ||||||
t Value | df | Sig (two-Tailed) | t Value | df | Sig (Two-Tailed) | ||||
NPC | |||||||||
Responsive (N = 28) | 10,178 ± 1347 b,c | 12,727 ± 2928 | −0.98 | 27 | 0.338 | 1.28 ± 0.18 | 1 | 31 | 0.325 |
Nonresponsive (n = 5) | 10,713 ± 3452 b | 6175 ± 1670 | 1.82 | 4 | 0.143 | 0.84 ± 0.22 | |||
Non-NPC HNC | |||||||||
Responsive (N = 7) | 11,018 ± 3509 c | 16,838 ± 4986 | −3.26 | 6 | 0.017 * | 1.97 ± 0.55 |
Factor | OR | 95% CI | p Value | |
---|---|---|---|---|
Age | 0.99 | 0.96 | 1.03 | 0.694 |
Gender | 0.76 | 0.34 | 1.67 | 0.488 |
Disease category | 0.245 | |||
NPC | 3.10 | 0.81 | 11.88 | 0.099 |
non-NPC HNC | 2.20 | 0.53 | 9.15 | 0.277 |
Disease stage | 1.03 | 0.64 | 1.67 | 0.896 |
Salivary amylase level at the first visit | 1.00 | 1.00 | 1.00 | 0.548 |
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Chen, Y.-C.; Viet-Nhi, N.-K.; Dang, L.H.; Su, C.-H.; Hung, S.-H. Efficacy of Office-Based Salivary Ductal Steroid Irrigation for Managing Post-Irradiation Xerostomia in Head and Neck Cancer Patients: A Retrospective Study. Biomedicines 2024, 12, 1033. https://doi.org/10.3390/biomedicines12051033
Chen Y-C, Viet-Nhi N-K, Dang LH, Su C-H, Hung S-H. Efficacy of Office-Based Salivary Ductal Steroid Irrigation for Managing Post-Irradiation Xerostomia in Head and Neck Cancer Patients: A Retrospective Study. Biomedicines. 2024; 12(5):1033. https://doi.org/10.3390/biomedicines12051033
Chicago/Turabian StyleChen, Yen-Chun, Nguyen-Kieu Viet-Nhi, Luong Huu Dang, Chin-Hui Su, and Shih-Han Hung. 2024. "Efficacy of Office-Based Salivary Ductal Steroid Irrigation for Managing Post-Irradiation Xerostomia in Head and Neck Cancer Patients: A Retrospective Study" Biomedicines 12, no. 5: 1033. https://doi.org/10.3390/biomedicines12051033