Posaconazole Alone and in Combination with Caspofungin for Treatment of Experimental Exserohilum rostratum Meningoencephalitis: Developing New Strategies for Treatment of Phaeohyphomycosis of the Central Nervous System
Abstract
:1. Introduction
2. Materials and Methods
2.1. Organisms and Inoculation
2.1.1. Organisms
2.1.2. Inoculum Preparation and Inoculation
2.2. Animals
2.3. Induction and Maintenance of Neutropenia and Immunosuppression
2.3.1. Neutropenia
2.3.2. Immunosuppression
2.3.3. Antibiotics
2.3.4. White Blood Cell Counts
2.4. Inoculum Response Relationship
2.5. Antifungal Compounds and Experimental Groups
2.6. Outcome Variables
2.6.1. Quantitative Cultures
2.6.2. (1→3)-β-d-Glucan Assay
2.7. Statistical Analysis
3. Results
3.1. Inoculum–Response Studies
3.2. Antifungal Therapy
4. Discussion
5. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Petraitiene, R.; Petraitis, V.; Maung, B.W.; Naing, E.; Kavaliauskas, P.; Walsh, T.J. Posaconazole Alone and in Combination with Caspofungin for Treatment of Experimental Exserohilum rostratum Meningoencephalitis: Developing New Strategies for Treatment of Phaeohyphomycosis of the Central Nervous System. J. Fungi 2020, 6, 33. https://doi.org/10.3390/jof6010033
Petraitiene R, Petraitis V, Maung BW, Naing E, Kavaliauskas P, Walsh TJ. Posaconazole Alone and in Combination with Caspofungin for Treatment of Experimental Exserohilum rostratum Meningoencephalitis: Developing New Strategies for Treatment of Phaeohyphomycosis of the Central Nervous System. Journal of Fungi. 2020; 6(1):33. https://doi.org/10.3390/jof6010033
Chicago/Turabian StylePetraitiene, Ruta, Vidmantas Petraitis, BoBo Win Maung, Ethan Naing, Povilas Kavaliauskas, and Thomas J. Walsh. 2020. "Posaconazole Alone and in Combination with Caspofungin for Treatment of Experimental Exserohilum rostratum Meningoencephalitis: Developing New Strategies for Treatment of Phaeohyphomycosis of the Central Nervous System" Journal of Fungi 6, no. 1: 33. https://doi.org/10.3390/jof6010033