Interactions between Bacteria and Aspergillus fumigatus in Airways: From the Mycobiome to Molecular Interactions
Abstract
:1. Introduction
2. Pulmonary Mycobiota and Chronic Respiratory Infections
3. Limitations of Studies and Laboratory Methodologies
4. Formation of Mixed Filamentous Fungi–Bacteria Biofilm
5. Extracellular Matrix Production
6. Social Interactions between Gram-Negative Bacteria and A. fumigatus in Mixed Biofilm
6.1. Antibiosis: The Most Common Social Interaction
6.2. Effect of Antibiosis Induced by the Bacteria on the Development of the Fungi
6.3. Strain-Dependent Interaction Effect
7. Effect of Extracellular Soluble Molecules of Bacteria on A. fumigatus Development
7.1. Role of P. aeruginosa Pyoverdine and Phenazines
7.2. Role of P. aeruginosa Quinolone Signal (PQS)
7.3. Role of Rhamnolipids and Elastase
7.4. Role of Volatile Organic Compounds
7.5. Role of Bacteriophages
8. Effect of Extracellular Soluble Molecules of Fungi on Bacterial Development (Figure 3)
8.1. Role of Gliotoxin
8.2. Role of A. fumigatus Siderophores
9. Role of Iron in Biofilm Interactions
10. Other Mechanisms
10.1. Apoptosis and ROS Production
10.2. Role of Oxygen and pH Gradients
11. Susceptibility of Polymicrobial Biofilms
12. Polymicrobial Biofilms Evasion of Immune System
13. Conclusions
Author Contributions
Funding
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Debourgogne, A.; Monpierre, L.; Sy, K.A.; Valsecchi, I.; Decousser, J.-W.; Botterel, F. Interactions between Bacteria and Aspergillus fumigatus in Airways: From the Mycobiome to Molecular Interactions. J. Fungi 2023, 9, 900. https://doi.org/10.3390/jof9090900
Debourgogne A, Monpierre L, Sy KA, Valsecchi I, Decousser J-W, Botterel F. Interactions between Bacteria and Aspergillus fumigatus in Airways: From the Mycobiome to Molecular Interactions. Journal of Fungi. 2023; 9(9):900. https://doi.org/10.3390/jof9090900
Chicago/Turabian StyleDebourgogne, Anne, Lorra Monpierre, Khadeeja Adam Sy, Isabel Valsecchi, Jean-Winoc Decousser, and Françoise Botterel. 2023. "Interactions between Bacteria and Aspergillus fumigatus in Airways: From the Mycobiome to Molecular Interactions" Journal of Fungi 9, no. 9: 900. https://doi.org/10.3390/jof9090900