Carbon Nanomaterials-Based Electrically Conductive Scaffolds to Repair the Ischaemic Heart Tissue

Round 1

Reviewer 1 Report

The manuscript entitled "Carbon Nanomaterials-Based Electrically Conductive Scaffolds to Repair the Ischaemic Heart Tissue" discusses the recent development in the conductive scaffold-based cardiac tissue engineering and reviews carbon nanomaterials for the conductive component of the scaffold. I recommend publishing the manuscript after minor revisions.

1. Carbon nanomaterials toxicity ( ex. shedding) should be discussed in detail. Are these scaffolds worth considering the toxic effects  and serious complications?

2. It would be good to discuss the longevity of these scaffolds. 

Author Response

Response to reviewer 1 comments

Thank you for taking the time to review the manuscript. All the points regarding toxicity and longevity of carbon nanomaterials have been discussed under the section "Drawbacks" in the updated version. 

Reviewer 2 Report

Comments: Manuscript is interesting, well written and it is strongly recommended to be published in journal of carbon research  after addressing of these few issues.

1-    The authors should discuss disadvantages of carbon nanomaterials, as well as their  potential side effects. Discuss why carbon nanomedicines are advantageous in  Ischaemic Heart Tissue, and how their accumulation may depend upon the properties of the nanoparticles (e.g. size, surface charge, shape).

2-    The manuscript is missing a comprehensive discussion If some formulations have reached already clinical applications, the authors should state it clearly and discuss the clinical results achieved.

Author Response

Response to reviewer 2 comments

Thank you for taking the time to review the manuscript. All the comments regarding point 1 and 2 have been addressed in the updated version under the section "Drawbacks".

Round 2

Reviewer 2 Report

Manuscript was revised point by point according to reviewer comments and It is more acceptable NOW.