ECSOC 2022 - 95 articles
Online | 15–30 November 2022
Volume Editor:
Julio A. Seijas, Universidad of Santiago De Compostela, Spain
Cholic acid is a trihydroxy bile acid with three hydroxy groups at C-3, C-7 and C-12 carbon atoms; two methyl groups at C-10 and C-13 carbon atoms of the steroid nucleus; and a carboxylic group at C24 of the side alkyl chain. The distance between the...
1,4-Butane-sultone functionalized graphitic carbon nitride nanosheets (g-C3N4@Bu-SO3H) was prepared and applied as an efficient heterogeneous catalyst for the synthesis of various quinazolines derivatives with high yield. In next step, the structure...
Asthma is a chronic obstructive pulmonary disease, affecting approximately 300 million people worldwide. Current therapies have disadvantages such as side effects and high costs. Alternatively, herbal plants have been used for decades as focal medici...
Aminobenzoic acid derivatives have shown various pharmacological properties, one of which is pesticide activity, giving these compounds the ability to work as alternatives to current pesticides. Nanotechnology could efficiently support the use of the...
The Schiff base ligand H2SB derived from the condensation of N-(2-aminobenzyl)-5-(dimethylamino)naphthalene-1-sulfonamide with 4-formyl-3-hydroxybenzoic acid has been investigated as a chemosensor for the detection of CdSe-Cys QDs in water samples. W...
Chitosan is a natural polysaccharide that is mainly obtained from the shell of marine crustaceans including crabs, lobsters, shrimps, etc. Chitosan has been widely used in biomedicine due to its special characteristics of low toxicity, biocompatibili...
There exist a number of classical methods for the synthesis of substituted pyrazines. Among this variety of reactions, the synthesis of substituted pyrazines from nitriles does not stand out in either the number of known examples or in product yield....
The search for new antibacterial drugs has continued to be an urgent matter. One of the approaches is the development of covalent inhibitors using biochemoinformatics at the initial stages. In this work, structures of a few plant-derived substances w...
The results of my research in the fields of theoretical studies and computer modeling of supramolecular chemical systems were presented. The main attention was focused on theoretical studies in the following topics: cycloaddition and nucleophilic add...
Two fluorescent sterol-like molecules have been synthesized, namely, a derivative of 7-nitrobenzofurazan (NBD) with 17-(methylamino)-androst-5-en-3beta-ol (DAM-NBD) and NBD-piperazine conjugate with cholesteryl chloroformate (NBD-pip-CCF). In silico...
The reductive cyclization of different organic nitro compounds by carbon monoxide, catalyzed by transition metal complexes, is a very efficient and clean strategy for the synthesis of many N-heterocycles. However, it requires the use of autoclaves an...
An efficient catalytic system consisting of 20 mol. % FeCl3·6H2O and 20 mol. % trifluoromethanesulfonic acid for the amidation of binor-S in a solution of toluene with organic nitriles under the action of microwave irradiation at 100 °C for...
Among the different green oxidative protocols, I2-catalyzed/DMSO systems have recently received considerable attention due to being greener, efficient, atom-economical, low-cost, and offering the possibility to perform reactions under safe and mild c...
Zn-containing proteins play essential roles in the viability and virulence of bacteria, so are considered to be possible molecular new drug targets. Based on literature data about N-acyl-o-phenylenediamine and 2-pycolylamine as warheads of drugs and...
A one-pot electrochemical synthesis of two medically interesting compounds is presented. 2-Phenylimidazo[1,2-a]pyridine and 2-(4-fluorobenzylidene)malononitrile were prepared using previously used starting materials. The reaction consists of electroc...
Bacterial infections have extensive impacts on public health. Therefore, finding compounds with antibacterial properties could serve as an effective method. A nanocomposite, Ag/CaO, was prepared from silver nitrate and egg shells. After calcination o...
The WHO database shows that mycobacterium tuberculosis has become an epidemic worldwide due to its pathogenicity and virulence, which have magnified its infectiousness. The situation becomes grimmer with the prevalence of MDR-TB, XDR-TB, emergence of...
2,5-DKPs are heterocyclic peptidomimetics, present in nature with high structural diversity, popular in the design of new bioactive molecules with potential application in medicinal chemistry, exhibiting anticancer and antimicrobial properties, among...
The increase in bacterial resistance to one or several antibiotics has become a global health problem. Nanocomposites have become a tool against multidrug-resistant bacteria. A nanocomposite, Ag2O/SrO/CaO, was prepared from AgNO3, SrCl2·6H2O,...
Polycyclic aromatic hydrocarbons are versatile building blocks for conjugated materials and can be applied in molecular electronics. Pyrenes are known as the best organic chromophores, and pyrene itself is known as an electron donor. Likewise, quinon...
Among the water pollution sources, heavy metals are considered the most hazardous because of their high toxicity to human health and their ability to badly damage the kidneys, brain, and nerves, as well as cause birth defects. Based on the promising...
The increasing tolerance and resistance of pathogens to conventional antibiotics is a global health issue, and there is a need to use effective and new substances. Metal–organic frameworks (MOFs) are highly functional materials with antimicrobi...
The fundamental importance of copper as a redox-active metal essential to the functioning of several metabolic enzymes provides a wide range of its biological activity pathways. Copper(II) coordination compounds are known to exhibit potent antiprolif...
The purpose of this work is to check the viability of mixtures of ionic liquids and lithium salt as electrolytes in Li- batteries. Firstly, the determination of the thermo-electrical properties of liquid mixtures of the ionic liquid N-butyl-N-methyl-...
A method for “P-ligand free”, Pd(OAc)2-catalyzed P–C coupling reactions under MW conditions was investigated in our group. In our latest work, this procedure was extended to dihalogenobenzenes. Copper-promoted reactions were studied...
With the emergence of technological advances, computational analysis in research has become promising by enabling the emergence of scientific production without the need for an experimental laboratory, and it has therefore begun to be used in various...
Grindelia ventanensis (Asteraceae) is an endemic species growing wild in Argentina. In this work, we studied the dichloromethane extract of this plant for their antioxidant activity and cholinesterase inhibition. This extract was fractionated using c...
The data obtained by the authors in the field of chemistry of substituted borolanes and 2,3-dihydro-1H-boroles are summarized. The authors developed a selective method for the synthesis of five-membered boracarbocycles via transmetalation of aluminac...
A metal-organic framework Zn2(BDC)2(DABCO) was employed as a reusable heterogeneous acidic catalyst in the acylation reaction of various benzaldehydes with acetic anhydride under microwave irradiation. The outstanding features of this efficient solve...
There is a trend to find new ways of using photocatalysis in order to synthesize valuable products or to control or track live processes with special fluorescence-based molecular probes. The paper presents some results concerning new photochemical pr...
We have previously obtained significant results in the cycloalumination of olefins with EtAlCl2 in the presence of magnesium and a Cp2ZrCl2 or Cp2TiCl2 catalyst. Here we report the development of an efficient one-pot catalytic method for the synthesi...
The preparation of enoxaparin via the base-promoted depolymerization of heparin is well known. In this paper, we present our efforts to convert this preparation into a flow method. Streams of base and ester solutions are combined and heated in a flow...
2-Benzoxazolone, as well as its derivatives, are valuable structural fragments of a number of important biologically active substances. 2-Benzoxazolone derivatives are promising as antitumor, antimicrobial, antiretroviral, anticonvulsant, tranquilizi...
Cyclodextrins (CDs) are macrocyclic oligosaccharides, containing between six and eight alpha(1 → 4)-linked glucopyranoses. CDs have a hydrophobic cone-shaped internal cavity and a hydrophilic exterior surface. They form non-covalent inclusion co...
In this work we present the microwave-assisted synthesis and in vitro acetylcholinesterase inhibition of a series of new caffeine derivatives. The design of these new compounds was inspired by the caffeine–pyrrolidine hybrids that act as AChE i...
The report presents data from our studies on obtaining lembehyne B derivatives with cytotoxic and neuritogenic activity. The methods and approaches to the synthesis of the above-mentioned lembehynes presented in the report are based on the use of the...
This study examined the rheological properties of alginates, one of the main products obtained from algae. These polysaccharides are widely used in fields such as pharmaceuticals, medical technology, cosmetics, food, agriculture and the textile and p...
In this work, we isolated a pentadentate [P2N2S] phosphine-thiocarbohydrazone ligand H2L with a bulky phosphine group in both linker domains that undergoes an oxidation process in solution. This ligand was synthesized by a direct reaction between two...
Derivatives of 1,3,5-oxadiazine are of interest to pharmacy, medicine, and agriculture as potential biologically active substances. These compounds have found wide application in organic synthesis and supramolecular chemistry. In this paper, we discu...
Lanthanide (Ln(III)) luminescent complexes have been attracting interest for technological applications and molecular imaging. The luminescence of Ln(III)) ions is weak and depends on the use of light absorbing coordination ligands which sensitizes t...
The pinewood nematode (PWN), Bursaphelenchus xylophilus, the causal agent of pine-wilt disease (PWD), is a threat to Pinus forests in Asia and Europe. Bursaphelenchus mucronatus and B. fraudulentus are closely related non-pathogenic pine-wood nematod...
A phenolic compound in Foeniculum vulgare can improve human health. Foeniculum vulgar contains flavonoids, glycosides, and other constituents that are used for medicinal ailments. Trans-anethole, fenchone, and estragole essential oils are the main in...
This work investigates the inclusion of the nimesulide molecule into the beta- and gamma- cyclodextrin cavity and explores the application of molecular modelling for the purposes of proving the host-guest complexation process. The author’s expe...
The crystal structures of mononuclear cyclopalladated compounds with phosphine ligands are investigated. The reactions of the five-membered cyclopalladated dinuclear complexes [Pd(L)(µ-Cl)]2 with the monophosphine ligand (PPh3) and diphosphine...
Graphitic carbon nitride-supported L-arginine (g-C3N4@L-arginine) has been prepared as a heterogeneous catalyst for synthesizing heterocyclic compounds such as pyranopyrazole and acridinedione derivatives. High efficiency, short reaction time, and ea...
Organophosphorus compounds have been investigated for agricultural and medicinal applications for decades, and a considerable number of phosphorus-containing drugs have achieved commercial success. A recent review by P. Finkbeiner et al. has shown th...
The infectious agent Mycobacterium tuberculosis (MTB) has several defense and resistance mechanisms that must be eliminated. The treatment is prolonged, which in many cases generates susceptibility to microbial resistance. This research aimed to stud...
Efficient methods for the synthesis of previously undescribed hybrid compounds based on monocarbonyl derivatives of curcumin and 5Z,9Z-dienoic acid with yields of 58–66% are presented. The key monomer, (5Z,9Z)-icosa-5,9-dienoic acid, was prepar...
A simple and fast procedure for estimation of the effect of chemical functionalization on the change in detonation properties of energetic materials is reported. The procedure consists of two levels. Computations at Level 1 can be performed with a po...
This work summarizes the results of a new approach to the synthesis of previously undescribed, hard-to-obtain five-membered cyclic organophosphorus compounds: 3-alkyl(aryl)-substituted phospholanes, α,ω-bisphospholanes, polycyclic phospho...
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