An Optimised Method to Synthesise N5O2 Aminophenols †
Abstract
:1. Introduction
2. Materials and Methods
2.1. Materials and General Methods
2.2. Synthesis
3. Results and Discussion
3.1. Synthesis of the Aminophenols
3.2. Characterisation of the Aminophenols
- The presence of two singlets in the region 3.5–4 ppm that integrate to 12 protons in total, indicating the existence of six CH2 groups and agreeing with the addition of the phenolic arms at the N5 precursor.
- The presence of nine signals in the aromatic region, which globally integrate to 17 protons, in agreement with the five aromatic rings, and, therefore, with the correct addition of the R-phenol to the N5 precursor.
- The presence of a singlet at 10 ppm (2H) and a second singlet at 2.3 ppm (6H) for H2LMe and at 3.73 for H2LOMe (6H), assigned to the hydroxyl and CH3 groups, respectively, also indicates the successful binding of the R-phenol to the precursor.
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Oreiro-Martínez, P.; Corredoira-Vázquez, J.; Sanmartín-Matalobos, J.; Fondo, M. An Optimised Method to Synthesise N5O2 Aminophenols. Chem. Proc. 2023, 14, 17. https://doi.org/10.3390/ecsoc-27-16145
Oreiro-Martínez P, Corredoira-Vázquez J, Sanmartín-Matalobos J, Fondo M. An Optimised Method to Synthesise N5O2 Aminophenols. Chemistry Proceedings. 2023; 14(1):17. https://doi.org/10.3390/ecsoc-27-16145
Chicago/Turabian StyleOreiro-Martínez, Paula, Julio Corredoira-Vázquez, Jesús Sanmartín-Matalobos, and Matilde Fondo. 2023. "An Optimised Method to Synthesise N5O2 Aminophenols" Chemistry Proceedings 14, no. 1: 17. https://doi.org/10.3390/ecsoc-27-16145