Investigating the Photophysical Properties and Biological Efficacy of BODIPY Derivatives as Photosensitizers in Photodynamic Therapy †
Abstract
:1. Introduction
2. Methods and Materials
2.1. Synthesis of BODIPY Derivative 2
2.2. Photophysical Characterization
2.3. Cell Culture and In Vitro Assays
2.3.1. Cellular Uptake Assay
2.3.2. Dark Toxicity and Phototoxicity of the BODIPY Derivatives
3. Results and Discussion
3.1. Synthesis and Photophysical Characterization of the BODIPY Derivatives
3.2. Photophysical Characterization
3.3. In Vitro Assays
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Compound | λabs (nm) | λfluo (nm) | ɸF | ɸΔ |
---|---|---|---|---|
1 | 508 a | 520 a | 0.82 a | 0.04 a |
505 b | 515 b | 0.43 b | 0.27 b | |
2 | 542 a | 559 a,b | 0.02 a | 0.93 a |
540 b | 0.003 b | 0.76 b | ||
3 | 507 a | 522 a | 0.08 a | 0.75 a |
502 b | 525 b | 0.02 b | 0.74 | |
4 | 521 a,b | 579 a | 0.52 a | nd a |
585 b | 0.35 b | 0.04 b |
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Gonçalves, R.C.R.; Pinto, S.C.S.; Pina, J.; Gomes-da-Silva, L.C.; Costa, S.P.G.; Raposo, M.M.M. Investigating the Photophysical Properties and Biological Efficacy of BODIPY Derivatives as Photosensitizers in Photodynamic Therapy. Chem. Proc. 2023, 14, 71. https://doi.org/10.3390/ecsoc-27-16094
Gonçalves RCR, Pinto SCS, Pina J, Gomes-da-Silva LC, Costa SPG, Raposo MMM. Investigating the Photophysical Properties and Biological Efficacy of BODIPY Derivatives as Photosensitizers in Photodynamic Therapy. Chemistry Proceedings. 2023; 14(1):71. https://doi.org/10.3390/ecsoc-27-16094
Chicago/Turabian StyleGonçalves, Raquel C. R., Sónia C. S. Pinto, João Pina, Lígia C. Gomes-da-Silva, Susana P. G. Costa, and M. Manuela M. Raposo. 2023. "Investigating the Photophysical Properties and Biological Efficacy of BODIPY Derivatives as Photosensitizers in Photodynamic Therapy" Chemistry Proceedings 14, no. 1: 71. https://doi.org/10.3390/ecsoc-27-16094