The physiological process of iodine uptake in the thyroid is used for
131I treatment of thyroid diseases. Children are more sensitive to radiation compared to adults and may react differently to
131I exposure. The aims of this study were to evaluate
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The physiological process of iodine uptake in the thyroid is used for
131I treatment of thyroid diseases. Children are more sensitive to radiation compared to adults and may react differently to
131I exposure. The aims of this study were to evaluate the effects on thyroid protein expression in young and adult rats one year after
131I injection and identify potential biomarkers related to
131I exposure, absorbed dose, and age. Twelve Sprague Dawley rats (young and adults) were i.v. injected with 50 kBq or 500 kBq
131I and killed twelve months later. Twelve untreated rats were used as age-matched controls. Quantitative proteomics, statistical analysis, and evaluation of biological effects were performed. The effects of irradiation were most prominent in young rats. Protein biomarker candidates were proposed related to age, absorbed dose, thyroid function, and cancer, and a panel was proposed for
131I exposure. In conclusion, the proteome of rat thyroid was differentially regulated twelve months after low-intermediate dose exposure to
131I in both young and adult rats. Several biomarker candidates are proposed for
131I exposure, age, and many of them are known to be related to thyroid function or thyroid cancer. Further research on human samples is needed for validation. Data are avaiable via ProteomeXchange with identifier PXD024786.
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