Internal and/or External Radiotherapy and Dosimetric Evaluation: From Cellular Level to the Patient

Dear Colleagues,

We are inviting submissions to the Special Issue on "Internal and/or External Radiotherapy and Dosimetric Evaluation: From Cellular Level to the Patient", which aims to cover the recent outstanding developments of radiotherapy and nuclear medicine treatments.  

Radiotherapy and nuclear medicine have a central role in the multidisciplinary field of oncology, either considered individually as possible way to irradiate tumors in combination with other modalities of treatment or in a combination of internal and external radiotherapy.

In recent years, both have experienced great improvements and developments, such as the increased number of particle therapy facilities worldwide; the concept of "theranostic"; a deeper understanding of tumor biology; improvements in imaging (together with radiomics and deep learning methods) from diagnosis and staging passing through treatment and finally to follow-up.

Although these are some of the goals achieved, the answers to questions ranging from the cellular level down to the patient remain opened. Some examples are: the possibility of using spectroscopy investigations to study cancer cell radioresistance; the basis to trigger a certain type of cell death after ionizing radiation treatment; the precise dosimetry evaluation of the treatment performed; dosimetric and radiobiological impact related to the treatment schedule with the possibility of a less toxic effect to normal tissues or improved tumor control/survival.

In this Special Issue, we invite you to contribute with original research articles exploring application of radiotherapy and/or nuclear medicine therapy on cell cultures and/or patients. Theoretical and experimental studies are welcome for submission, as well as are comprehensive reviews and editorials.

Potential topics include, but are not limited to:

• Basic research on cell cultures exposed to ionizing radiation;
• Spectroscopic investigation on cell cultures exposed to ionizing radiation;
• Dosimetry and radiobiological study at the cellular and/or animal level;
• Radiobiology analysis of in vitro assays with tumor cell lines and in animal models of cancer;
• Diagnostic nuclear medicine (PET, SPECT, and hybrid imaging);
• Quantitative imaging;
• Advances in nuclear medicine dosimetry;
• Therapeutic nuclear medicine;
• Advances in radiotherapy planning and delivery;
• Basic research in radiotherapy;
• Pre-treatment and/or in vivo dosimetric evaluation of ionizing radiation treatments or online dosimetry;
• Software and instruments for dose assessment;
• Radiomics;
• Predictive models.

Dr. Emilio Mezzenga
Dr. Lidia Strigari
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.