Research Progress in Cellular and Molecular Mechanisms of the Blood–Brain Barrier

Dear Colleagues,

The blood–brain barrier permits essential nutrients to enter and leave the brain by crossing the luminal and abluminal membranes on facilitative carriers. The endothelial cells of brain capillaries are well supplied with mitochondria, implying that they are capable of energic activity. Recently, sodium-dependent carriers were described in the abluminal membranes positioned to move more than 20 molecules (some of which are osmolytes or medicines) toward the blood. Physiological evidence exists that glutamate is actively removed from the brain. This leads to the recognition that cerebral capillaries are active, rather than passive, participants in regulating the content of soluble molecules in the brain. For this Special Issue, articles that relate to the dynamic physiological function of the blood–brain barrier in regulating the brain’s internal environment are welcome for submission.

Prof. Dr. Richard A. Hawkins
Prof. Dr. Juan Viña
Prof. Dr. Darryl R. Peterson
Guest Editors

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