Special Issue "RNA Viruses and Cancer"
A special issue of Biology (ISSN 2079-7737).
Deadline for manuscript submissions: closed (31 January 2013)
Prof. Dr. Santanu Bose
Department of Microbiology and Immunology, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
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Phone: +1 210 567 1019
Fax: +1 210 567 6612
Interests: respiratory RNA virus infections; oncolytic RNA viruses; oncolytic RNA virus based anti-cancer therapeutics
RNA viruses are important class of human pathogens that causes an array of human diseases. RNA viruses can also act as oncoviruses to promote cancer development (oncogenesis). For example, retrovirus like Human T lymphotrophic virus type 1 (HTLV-I) has been associated to T-cell leukemia, while hepatitis C virus (HCV) has been linked to development of liver cancer. Several RNA viruses also possess anti-cancer property. Known as oncolytic viruses, these viruses specifically “kills” cancer cells, but not normal cells. RNA viruses that possess oncolytic activity are vesicular stomatitis virus (VSV), measles virus, respiratory syncytial virus (RSV), Newcastle disease virus (NDV), mumps virus, reovirus, coxsackie virus, poliovirus. In the last decade major stride has been made in understanding the mechanism of oncogenesis by HTLV-I and HCV. These have led to development of treatment regimen to combat virus-associated cancers. Similarly, research with oncolytic viruses has illustrated the possible usage of these natural or genetically engineered “anti-cancer” viruses to treat various cancers and solid tumors either alone or in combination with other non-virus cancer agents (radiation, chemotherapy etc). This has culminated in major progress for development of safe and efficacious oncolytic viruses that can specifically target cancer cells (and tumors). This special issue will publish original research papers and review articles on RNA oncovirues (HTLV-I and HCV) and oncolytic viruses that possess RNA genome.
Prof. Dr. Santanu Bose
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 650 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- RNA oncoviruses
- RNA oncolytic viruses
- Hepatitis C virus (HCV)
- Human T lymphotrophic virus type 1 (HTLV-I)