From Gene Variant to Variant Function: Recent Advances in Cancer Genetics

Dear Colleagues,

In the era of personalized cancer medicine, the discovery and functional characterization of sequence variants found in cancer-related genes are of utmost importance. Although the massive parallel sequencing (MPS) of partial or whole cancer genomes is steadily replacing targeted amplicon sequencing, the generation of such a large amount of data is still a bottleneck for its application in routine clinical practice. In this light, the development of new bioinformatic tools and approaches for the classification of variants of uncertain/unknown significance (VUS), as well as the design of cancer Furthermore, for the identification of cancer-causing mutations,  databases of genetic variants found in healthy individuals with different population backgrounds are equally important. However, we can only achieve fully personalized cancer medicine, with therapies tailored according to the individual’s cancer genomic profile, when we are able to understand the function of each and every single nucleotide in the human genome.

This Special Issue titled “From Gene Variant to Variant Function: Recent Advances in Cancer Genetics” invites authors to contribute to different areas of cancer genetics and genomics research with either original research articles or comprehensive literature reviews.

Dr. Petar Ozretić
Dr. Vesna Musani
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• advancements in DNA analysis and variant detection
• genetic association studies and the discovery of new cancer-driver genes
• diagnostic, prognostic, and predictive genetic cancer biomarkers
• locus-specific and comprehensive cancer genetic variation databases
• in silico classification of genetic variants
• functional analysis of genetic variants
• development of mutation-targeted therapies