Basic and Clinical Researches of Antiphospholipid Syndrome: 2nd Edition

Dear Colleagues,

We cordially invite you to contribute your research to the Special Issue titled “Basic and Clinical Researches of Antiphospholipid Syndrome: 2nd Edition”.

Antiphospholipid syndrome (APS) is a systemic autoimmune disorder known as acquired thrombophilia, characterized by vascular thrombosis and/or pregnancy-related morbidity in the presence of persistently positive antiphospholipid antibodies. "Seronegative APS" represents patients who have only clinical manifestations without laboratory confirmation, i.e., those that do not meet the standard classification criteria for APS and are therefore less likely to be treated, which carries the risk of recurrent thrombosis and/or pregnancy loss.

The heterogeneity and non-specificity of potential clinical signs highlight that APS is a true systemic autoimmune disease and underscores the need for a better understanding of disease mechanisms to facilitate a personalized treatment approach. In the general population, the incidence of clinical manifestations of APS is high and could often be triggered by many other underlying factors. Therefore, the diagnosis of APS primarily relies on laboratory measurements. However, current laboratory tests are hampered by technical limitations in the preanalytical and analytical phases.

This Special Issue aims to collate research articles and reviews on the pathogenic mechanisms underlying APS in order to provide new insights at the molecular level and refine understanding on disease development and progression, with the hope of consequently improving APS diagnosis.

Dr. Polona Žigon
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• antiphospholipid snydrome
• antiphospholipid antibodies
• thrombosis
• obstetric morbidity
• thrombophilia
• APS novel markers
• non-criteria manifestations
• pathogenesis

• Basic and Clinical Researches of Antiphospholipid Syndrome in Biomedicines (11 articles)