Molecular and Cellular Level of Pancreatic Cancer
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cancer Biology and Oncology".
Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 102
Special Issue Editor
Special Issue Information
Dear Colleagues,
Pancreatic cancer is a complex disease with multiple molecular mechanisms involved in its development and progression. One of the key drivers of pancreatic cancer is the KRAS gene, which is mutated in up to 90% of cases. This mutation leads to uncontrolled cell growth and division, contributing to tumor formation. Other genetic mutations, such as those in TP53, CDKN2A, and SMAD4, are also commonly found in pancreatic cancer and can further promote tumor growth and metastasis. In addition to genetic mutations, epigenetic changes, such as DNA methylation and histone modifications, can also play a role in pancreatic cancer development. The immune system is also implicated in pancreatic cancer, as it can either suppress or promote tumor growth depending on the context. Overall, understanding the molecular mechanisms of pancreatic cancer is crucial for developing effective treatments and improving patient outcomes.
Dr. Masataka Kikuyama
Guest Editor
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Keywords
- early diagnosis
- pancreatic carcinoma in situ
- pancreatic intraepithelial neoplasia
- chemotherapy
- immunotherapy
- radiation
