From Molecules to Medicine: Deciphering Obesity and Lipid Metabolism for Translational Insights

Dear Colleagues,

Obesity has reached alarming proportions, affecting over half a billion adults worldwide. It serves as a major risk factor for type 2 diabetes, hypertension, cardiovascular diseases, cancers, and infection. The link between type 2 diabetes and obesity is well established, accompanied with insulin resistance and hyperinsulinemia, intensifying the severity of the disease. These metabolic disorders contribute to an overburdened healthcare system, increased mortality, and overall diminished quality of life. Drugs, used alone or in combination with lifestyle modifications and surgery, are a cornerstone for treatment. However, the efficacy of many drugs designed to manage metabolic disorders is suboptimal, and they are often accompanied by off-target side effects.

This Special Issue is dedicated to exploring innovative approaches to address metabolic disorders, with a primary focus on obesity, type 2 diabetes, and insulin resistance. The emphasis lies on the identification of novel molecules and advanced strategies to enhance drug efficacy, improve specificity, and maximize overall effectiveness in the treatment of these metabolic disorders.

Dr. Abhishek Gupta
Dr. Sandeep Kumar
Guest Editors

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• obesity
• insulin resistance
• lipid metabolism
• drug discovery