Prevention and Treatment of Skin Pathologies: New Leads and Approaches for an Old Problem

Dear Colleagues,

Considered the largest human organ, skin forms a barrier against many external stressors, including abiotic (e.g., UV light, temperature, chemicals), pathogens (e.g., viruses, bacteria, fungi), or mechanical/physical injuries. Skin is also very important for body physiology and homeostasis, helping in controlling body temperature and hydration, excreting xenobiotics, and acting as a sensory organ. Therefore, is not surprising that many skin pathologies exist, representing an important health issue and a burden for public social services.

Many diseases are associated with complex traits resulting from genetic and immune factors (e.g., vitiligo, psoriasis, lupus). Others result directly or indirectly from external insults (xenobiotics, pathogens, UV, etc.) that can cause more benign aesthetic skin conditions (e.g., pigmentation, atopic dermatitis), local inflammation and infectious skin diseases, as well as deadly malignant melanoma. At present, pressure ulcers and chronic wounds, incremented by population ageing, diabetes condition and antibiotic bacterial resistance, are becoming important issues not only for patients but also for health systems.

Many skin pathologies are long-known realities, but the biochemical and cellular mechanisms regulating the occurrence of many of these conditions are still not fully understood, and in many cases no effective therapies exist.

Taking this into consideration, submissions of original research or review articles are welcome, with topics including but not limited to:

• New putative leads, including synthetic, semisynthetic, or natural compounds and products.
• Intervention in known pathways or the investigation of new ones.
• New molecular targets.
• Innovative therapies and medical devices.
• New formulations and delivery systems, including the use of nanotechnologies.

Dr. Alberto C. P. Dias
Guest Editor

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• skin diseases
• new leads
• natural products and compounds
• molecular targets
• inflammation
• skin infectious diseases
• skin immunity
• oxidative stress and genotoxicity
• formulations and medical devices
• nanotechnology