Advances in Atherothrombotic Diseases

Dear Colleagues,

Atherothrombosis is one of the major causes of morbidity and mortality in the occidental world. Cardiovascular risk factors such as hypertension, insulin resistance, type 2 diabetes, dyslipidemia, smoking, obesity, sedentary life, oxidative stress, and genetic factors induce the formation of atherosclerotic plaques in the lumen of medium and large arteries like the carotids and aorta, as well as the coronary and peripheral arteries of the lower limbs. Several cells are involved in atherogenesis, including endothelial cells, vascular smooth muscle cells, monocytes/macrophages, lymphocytes, and platelets. Plaque rupture causes the release of many proinflammatory cells and mediators, the partial reduction in blood flow, or obstruction, which is why the process of atherosclerosis plays a crucial role in the development of cardiovascular and cerebrovascular diseases such as acute myocardial infarction, heart failure, angina pectoris, transient ischemic attack, stroke, and claudicatio intermittens.

This Special Issue will therefore welcome original articles and reviews that focus on atherothrombosis, and the cellular and molecular pathways involved in its development. Studies that assess the effects of current therapies to prevent atherothrombosis and to protect patients from the development of cardio- and cerebrovascular events will also be welcomed.

Dr. Cristina Barale
Guest Editor

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• atherothrombosis
• cardiovascular risk factors
• atherosclerosis
• endothelial cells
• vascular smooth muscle cells
• platelets
• cardiovascular events