Peripheral Artery Disease and Diabetic Foot Ulcer: From Bench to Clinic (2nd Edition)

Dear Colleagues,

Peripheral artery diseases (PAD) and diabetic foot ulcers (DFU) are life-threatening diseases in the Western world, with crucial importance to the medical field, as they have a major impact on the patient’s quality of life and lead to significant costs for the healthcare system. DFU represent a chronic complication in patients with diabetes; they are often associated with neuropathy and/or peripheral artery disease (PAD) of the lower limb in diabetic patients. PAD is a result of atherosclerosis. The major complication of DFU and PAD is lower limb amputation. Diagnosing PAD is a challenge, as it is asymptomatic in most patients in the early stages and it presents in various ways. Conventional treatments for DFU, including debridement, revascularization, management of infection, and off-loading, have not been shown to be effective enough, and they were not able to reduce the amputation rate. As a result, alternative or additional treatment and new therapeutical approaches in regenerative medicine are required. Furthermore, extra clinical data concerning the risk factors of PAD and DFU, as well as their impact on patients' lives and the healthcare system, are still needed. Molecular inflammatory processes initiating the progress of PAD in diabetics and non-diabetics are still unclear and need to be investigated to create new therapeutical approaches.

Prof. Dr. Irene Hinterseher
Dr. Racha El Hage
Guest Editors

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• peripheral artery diseases
• diabetic foot ulcer
• atherosclerosis
• regenerative medicine
• inflammatory