Research Advances in Kidney Diseases and Sepsis

Dear Colleagues,

Sepsis and kidney diseases have a strong interrelationship, as they mutually increase the risk of one another. Kidney disease can contribute to the development of sepsis, particularly in individuals undergoing dialysis who possess a vascular access site such as a catheter, graft or fistula beneath their skin and within a blood vessel. This access point provides an avenue for pathogens to directly enter the bloodstream. Furthermore, chronic kidney disease can compromise the immune system's functionality, thereby elevating susceptibility to severe infections. Additionally, certain medications utilized post-kidney transplant surgery (such as anti-rejection drugs) may weaken the immune response. Infections can arise from kidney stones and potentially disseminate throughout the body, leading to sepsis. Sepsis can lead to systemic dysfunction, resulting in multi-organ failure, often initiating with renal impairment. Hypotension may ensue, leading to compromised perfusion of oxygen and nutrients to the kidneys. Additionally, intravascular coagulation can impede renal oxygenation. It is estimated that sepsis accounts for approximately one-third to one-half of cases involving acute kidney injury.

This Special Issue of Biomedicines will focus on sepsis and kidney disease via articles or reviews dealing with pathophysiology, diagnosis, biomarkers and treatment are welcome.

Dr. Eiichi Sato
Guest Editor

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• sepsis
• acute kidney injury
• dialysis
• kidney failure
• immune system