Coronary Heart Disease: Causes, Pathology and Treatment

Dear Colleagues,

Coronary heart disease (CHD) is a prevalent cardiovascular condition with high morbidity and mortality.

It is characterized by the progressive development of atherosclerotic plaques, which cause a narrowing of the internal lumen of the coronary arteries, thus reducing the blood flow to the metabolically high demand of myocardium.

It may be complicated by rupture or erosion of the atheromatous plaques, giving rise to acute coronary events such as acute myocardial infarction.  

The issue explores various aspects related to the causes, pathology, and treatment options for coronary heart disease (CHD), shedding light on the latest research and advancements in the field.

Coronary atherosclerosis is initiated by the accumulation of oxidized low-density lipoprotein cholesterol in the arterial wall, a process which is believed to be facilitated by local inflammation.

Several risk factors contribute to the development of CHD. These include modifiable factors such as hypertension, diabetes, dyslipidemia, smoking, obesity, and a sedentary lifestyle. Non-modifiable factors, including age, gender, and family history, also play a role in susceptibility to CHD.

Understanding the pathology of CHD is essential for effective management. The pathology of CHD involves the progressive development of atherosclerotic plaques within the coronary arteries. It includes the cellular and molecular mechanisms involved in plaque formation, including cholesterol accumulation, inflammatory processes, and endothelial dysfunction.

The management of coronary heart disease (CHD) aims to alleviate symptoms, prevent complications, and reduce the risk of future cardiac events. Pharmacological interventions targeting lipid management, blood pressure and diabetes control, antiplatelet therapy and symptom relief are thoroughly discussed. Also included are the noninvasive and invasive diagnostic procedures and cardiac rehabilitation.

The Special Issue "Coronary Heart Disease: Causes, Pathology and Treatment" serves as a valuable resource for researchers, clinicians, and healthcare professionals involved in the field of cardiovascular medicine. It provides a comprehensive understanding of the causes, pathology, and treatment options for CHD, emphasizing the importance of preventive measures, risk factor management, and personalized therapeutic approaches.

Dr. Joseph A. Moutiris
Dr. Dimitrios A. Vrachatis
Guest Editors

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• CHD
• dyslipidemia
• hypertension
• diabetes
• myocardial infarction
• cardiac rehabilitation
• cardiovascular prevention