Fatty Liver Disease: From Mechanisms to Therapeutic Approaches

Dear Colleagues,

The liver, as the largest organ, participates in food digestion, energy storage and the removal of toxic substances removal from the body, thus having a major impact on the general health of patients. Excessive buildup of fat in the liver is known as fatty liver, which is becoming increasingly common around the world. Mechanistic accumulation of fat can be related to alcohol toxicity, but the majority of cases nowadays are non-alcohol-related, so this form of fatty liver disease has been renamed to Metabolic dysfunction-associated fatty liver disease (MAFLD). This suggests that a plethora of possible mechanisms are involved in the buildup of fat in the liver, with the possible impact of sex hormones on metabolism needing further study. Excessive fat accumulation can go unnoticed until serious liver dysfunction occurs, disrupting organism homeostasis and possibly resulting in extrahepatic organ pathologies. Fatty liver disease coexists with other diseases like diabetes, cardiovascular diseases, and neurodegenerative diseases, and their connection can no longer be overlooked.

Manuscripts that are being accepted for this Special Issue are those that address the mechanisms of fat accumulation, correlation with other diseases, and the possible effects of sex differences. In addition, manuscripts addressing clinical data, possible early detection, and therapies for fatty liver are also welcome.

Dr. Mirela Baus Lončar
Guest Editor

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• fatty liver
• metabolism
• animal models of disease
• gut–liver–brain axis
• therapy