Targeting Cell Metabolism as Cancer Therapy (Closed)

A topical collection in Biomedicines (ISSN 2227-9059). This collection belongs to the section "Cancer Biology and Oncology".

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Editor


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Guest Editor
1. NF-kB, Differenciation and Cancer, University Paris Descartes, Sorbonne Paris Cité, 75014 Paris, France
2. Faculté de Pharmacie, 4 Avenue de l'Observatoire, 75006 Paris, France
Interests: interface between signal transduction and cancer with a focus on the alternative NF-kappaB signaling pathway, how it is regulated, and its contributions towards tumor development and resistance to conventional cancer therapies
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Topical Collection Information

Dear Colleagues,

Reprogramming of energy metabolism in cancer has recently been recognized as one of the hallmarks of cancer and its understanding will contribute to the development of new anticancer strategies and/or improve the effectiveness of existing therapies.

This Topical Collection aims to publish research on the metabolic features of solid and hematological cancers, including cancer cells and the tumor microenvironment, and how to exploit the metabolic perturbations to develop new anticancer treatments.

We invite research and review papers covering all aspects of cancer cell metabolism and related innovative cancer therapies. Topics include, but are not limited to, fundamental understanding of metabolic disturbance in cancer, associated gene expression profiling, epigenetic regulation, metabolomics, diagnostic and prognostic biomarkers, molecular targets, cancer drug development targeting metabolism, clinical trials with new agents, and validation in animal models.

Dr. Veronique Baud
Collection Editor

Manuscript Submission Information

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Keywords

  • Reprogramming of metabolic pathways in cancer cells
  • Deciphering metabolic signaling pathways
  • Cancer metabolism related to:
    • gene expression profiling
    • metabolomics
    • epigenetics
    • oncogenomics
    • biomarkers
    • cancer targeted diagnosis
    • cancer-targeted therapeutics
    • innovative anti-metabolic therapies
    • mechanism-based drug development
    • drug discovery
    • clinical trials
    • animal models

 

Published Papers (1 paper)

2021

10 pages, 10019 KiB  
Article
Results of TETimaX Trial of Langerhans Cell Histiocytosis Treatment and Perspectives on the Role of Imatinib Mesylate in the Era of MAPK Signaling
by Liliana Montella, Margaret Ottaviano, Vittorio Riccio, Fernanda Picozzi, Gaetano Facchini, Luigi Insabato, Mario Giuliano and Giovannella Palmieri
Biomedicines 2021, 9(12), 1759; https://doi.org/10.3390/biomedicines9121759 - 24 Nov 2021
Cited by 2 | Viewed by 1872
Abstract
Langerhans cell histiocytosis (LCH) is a rare disease that has a variable clinical presentation and unpredictable behavior. Until recently, therapeutic options were limited. Insights into the role of mitogen-activated protein kinase (MAPK) signaling have allowed the increased use of targeted treatments. Before the [...] Read more.
Langerhans cell histiocytosis (LCH) is a rare disease that has a variable clinical presentation and unpredictable behavior. Until recently, therapeutic options were limited. Insights into the role of mitogen-activated protein kinase (MAPK) signaling have allowed the increased use of targeted treatments. Before the advent of drugs that interfere with this pathway, investigations concerning the tyrosine kinase inhibitor imatinib opened the way to a rationale-based therapeutic approach to the disease. Imatinib block the binding site of ATP in the BCR/ABL protein and is also a platelet-derived growth factor receptor (PDGFR) and a KIT (CD117) kinase inhibitor. A case of refractory LCH with brain involvement was reported to be successfully treated with imatinib. Thereafter, we further explored the role of this tyrosine kinase inhibitor. The present study is composed of an immunohistochemical evaluation of PDGFRβ expression and a clinical evaluation of imatinib in a series of LCH patients. In the first part, a series of 10 samples obtained from LCH patients was examined and a strong immunohistochemistry expression of PDGFRβ was found in 40% of the cases. In the clinical part of the study, five patients were enrolled. Long-lasting disease control was obtained. These results may suggest a potential role for this drug in the current age. Full article
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