Diagnosis, Pathogenesis and Treatment of Pancreatic Ductal Adenocarcinoma

Dear Colleagues,

Pancreatic ductal adenocarcinoma (PDAC) is the most common form of pancreatic cancer, originating from the epithelial cells of the main pancreatic duct.

The pathogenesis of PDAC is not fully understood, but includes various risk factors such as genetic predisposition, chronic pancreatitis, smoking, obesity, and diabetes. Genetic mutations play a significant role in the development of PDAC, with KRAS, TP53, and CDKN2A among the most commonly altered genes.

Treatment for PDAC depends on the stage of the cancer and the patient's overall health status. Early stage disease may be treated with surgical resection, while later stages or metastatic PDAC might require chemotherapy, radiation therapy, or targeted therapy. Novel treatment approaches, such as immunotherapy and personalized medicine, are being explored in order to improve patient outcomes.

This Special Issue aims to provide an overview of the advancements in preclinical and clinical practices in the field of the treatment of PDAC. We invite authors to submit original research and review articles focusing on this important topic.

Dr. Teresa Perra
Prof. Dr. Alberto Porcu
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• pancreatic cancer
• pancreatic ductal adenocarcinoma
• treatment
• management
• complications
• vascular reconstruction
• neoadjuvant therapy