Growth Factors of the Peripheral Nervous System and Neurotrophin Family
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Neurobiology and Clinical Neuroscience".
Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 148
Special Issue Editor
Interests: peripheral nervous system; primary sensory neurons; dorsal root ganglia; mechanoreceptors; cutaneous end-organ complexes (sensory corpuscles)
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Special Issue Information
Dear Colleagues，
The growth factors included in the family of neurotrophins (NGF, BDNF, NT3, NT4/5 and NT6—the latter only present in fish) constitute the paradigm of bioactive molecules with neurotrophic and neurotropic activities, especially in the peripheral nervous system. Almost 75 years have passed since the first member of the family (NGF) was discovered, and more than 30 years since the discovery of the high-affinity receptors that signal its biological functions. It is, therefore, a good time to recapitulate and update the knowledge of the influence of growth factors of the neurotrophin family on the development and maintenance of discrete neuronal populations in the peripheral nervous system. It was originally established that NGF was related to nociceptive primary sensory neurons and peripheral sympathetic neurons, BDNF to touch mechanoreceptive primary sensory neurons, NT3 to proprioceptive primary sensory neurons and to the enteric nervous system. But it was found that the relationships of the growth factors of this family with the peripheral nervous system are much more complex. It would be of the utmost interest to the scientific community, especially those interested in neuroscience, to organize a set of manuscripts in which previous data are compiled and the new data on this exciting subject are provided. Likewise, it is of the utmost interest to compile the therapeutic potential of this family of growth factors in the treatment of peripheral neuropathies and pathologies of the peripheral nervous system due to mutations in neurotrophins or their receptors, such as insensitivity to pain with anhidrosis.
Prof. Dr. José A. Vega
Guest Editor
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Keywords
- nerve growth factor (NGF)
- brain-derived neurotrophic factor (BDNF)
- neurotrophin 3 (NT3)
- dorsal root ganglia
- sensory ganglia of the cranial nerves
- sympathetic ganglia
- enteric nervous system
