Mechanisms of Cell Death in Cancer Cells: A New Therapeutic Opportunity—2nd Edition

Dear Colleagues,

Cancer initiation and progression are driven by a complex interplay of genetic errors, environmental factors, and dysregulated molecular pathways. Among these pathways, the mechanism of cell death plays a critical role in regulating tumor growth and survival. Alterations in cell death pathways enable cancer cells to evade apoptosis, proliferate uncontrollably, and resist therapy. Therefore, targeting these pathways represents a promising therapeutic strategy for combating cancer.

This Special Issue aims to showcase cutting-edge research focused on elucidating the molecular mechanisms underlying cell death dysregulation in cancer and identifying novel therapeutic compounds capable of restoring its normal function. The featured studies will highlight both newly discovered molecules and repurposed drugs, offering insights into innovative strategies for overcoming treatment resistance and improving patient outcomes in both solid tumors and hematological malignancies.

The research presented in this collection will delve into the intricate molecular events driving cell death dysregulation in cancer, including disruptions in signaling cascades, DNA repair mechanisms, and the aberrant expression of regulatory proteins. Furthermore, the impact of environmental factors such as carcinogen exposure and chronic inflammation on these processes will be explored. By unraveling the complex mechanisms governing cell death in cancer, researchers aim to identify vulnerabilities that can be exploited for therapeutic intervention.

Through comprehensive exploration of the cell death machinery, this Special Issue seeks to accelerate the development of effective anti-cancer therapies with broad applicability across diverse cancer types. By highlighting promising compounds and therapeutic approaches, the collection aims to provide valuable insights into the future of cancer treatment and pave the way for improved outcomes for patients worldwide.

Dr. Adrian-Bogdan Țigu
Guest Editor

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• cell death
• drug repositioning
• translational research
• oncology
• cancer therapy
• apoptosis

• Mechanisms of Cell Death in Cancer Cells: A New Therapeutic Opportunity in Biomedicines (9 articles)