Inflammatory Signaling in Vascular Endothelial Cells
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".
Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 90
Special Issue Editor
Interests: vascular inflammation and atherosclerosis; extracellular matrix (ECM) remodeling; ECM/integrin-dependent endothelial signaling and phenotype; fluid shear stress-dependent endothelial mechanotransduction
Special Issue Information
Dear Colleagues,
Endothelial cells lining the innermost layer of vasculatures actively participate in homeostasis maintenance in healthy individuals and remodeling processes in development or pathological conditions. These cells are exposed to and respond to blood flow, regulate blood vessel dilation, and promote barrier function, protecting surrounding tissues from fluid leakage or pathogen infiltration. Endothelial cells are part of immune systems and contribute to host defenses by actively participating in inflammation via recruiting immune cells such as monocytes and T-cells. This endothelial inflammation is tightly controlled by mechanisms such as laminar blood flow-induced KLF2 signaling. However, sterile endothelial inflammation involving the key inflammatory mediators NFkB or Yap, triggered by many different humoral or mechanical factors, often leads to various vascular diseases including atherosclerosis, aortic aneurysms, and pulmonary arterial hypertension. The aim of this Special Issue is to provide readers updated research on endothelial function in vascular inflammatory diseases in the form of reviews and novel research articles. The issue will cover various topics related to vascular inflammation, including but not limited to:
- Mechanism of endothelial inflammatory signaling;
- Function of endothelial cells and their inflammatory signaling in diseases;
- Endothelial phenotypes and plasticity in inflammatory diseases;
- Endothelial inflammation regulated by metabolic pathways;
- Endothelial mechanotransduction and inflammation.
Dr. Sanguk Yun
Guest Editor
Manuscript Submission Information
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Keywords
- vascular inflammation
- endothelial cells
- endothelial dysfunction
- vascular diseases
- endothelial phenotypes
