Regulatory T Lymphocytes: Three Decades with Odette-and-Odile in Human Diseases

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Gene and Cell Therapy".

Deadline for manuscript submissions: closed (31 May 2024) | Viewed by 972

Special Issue Editor


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Guest Editor
1. Department of Life Sciences, European University Cyprus, 2404 Nicosia, Cyprus
2. School of Infection and Immunity, University of Glasgow, Glasgow G12 8TA, UK
Interests: tumor immunology; autoimmunity; RNA sequencing; immunotranscriptomics; translational oncology; immunoregulatory cytokines
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Special Issue Information

Dear Colleagues,

Responses of the immune system are controlled by regulatory mechanisms guided by specific immunoreactive and suppressive cellular compartments, including regulatory lymphocytes, macrophages, and myeloid-derived suppressor cells. The first described immune cell population with regulatory properties was the regulatory T cells (Tregs), almost 30 years ago. Since the first report on their implication in the development of autoimmunity in experimental models, Tregs have attracted great research interest and have been proven pivotal players in any condition where the control of immune response may be critical.

In vivo and in vitro experiments have revealed their implication in the development and perpetuation of human disorders in the fields of autoimmunity, cancer, allergy, asthma, and others, and indicated their potential as possible therapeutic targets. Indeed, certain Treg subsets have entered clinical trials for possible use in adoptive T cell therapy, though with many obstacles that need to be overcome. On the other hand, studies on large clinical cohorts have suggested the ability of these cells to serve as prognostic biomarkers for patients’ survival and response to therapy. Furthermore, a series of studies were devoted to the development of methods and the identification of markers for their optimal assessment and evaluation of their function in humans and in mice.

In this commemorative Special Issue, we welcome submissions of research works on the involvement of Tregs in any human disorder where the immune microenvironment plays a key pathogenetic role, and/or on their capacity to enhance the diagnostic and therapeutic clinical armamentarium. 

Dr. Marianna Christodoulou
Guest Editor

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Keywords

  • Tregs
  • autoimmunity
  • cancer
  • asthma
  • transplantation
  • allergy
  • immunotherapy
  • biomarker
  • diagnostics

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