Regulatory T Lymphocytes: Three Decades with Odette-and-Odile in Human Diseases
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Gene and Cell Therapy".
Deadline for manuscript submissions: closed (31 May 2024) | Viewed by 972
Special Issue Editor
2. School of Infection and Immunity, University of Glasgow, Glasgow G12 8TA, UK
Interests: tumor immunology; autoimmunity; RNA sequencing; immunotranscriptomics; translational oncology; immunoregulatory cytokines
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Responses of the immune system are controlled by regulatory mechanisms guided by specific immunoreactive and suppressive cellular compartments, including regulatory lymphocytes, macrophages, and myeloid-derived suppressor cells. The first described immune cell population with regulatory properties was the regulatory T cells (Tregs), almost 30 years ago. Since the first report on their implication in the development of autoimmunity in experimental models, Tregs have attracted great research interest and have been proven pivotal players in any condition where the control of immune response may be critical.
In vivo and in vitro experiments have revealed their implication in the development and perpetuation of human disorders in the fields of autoimmunity, cancer, allergy, asthma, and others, and indicated their potential as possible therapeutic targets. Indeed, certain Treg subsets have entered clinical trials for possible use in adoptive T cell therapy, though with many obstacles that need to be overcome. On the other hand, studies on large clinical cohorts have suggested the ability of these cells to serve as prognostic biomarkers for patients’ survival and response to therapy. Furthermore, a series of studies were devoted to the development of methods and the identification of markers for their optimal assessment and evaluation of their function in humans and in mice.
In this commemorative Special Issue, we welcome submissions of research works on the involvement of Tregs in any human disorder where the immune microenvironment plays a key pathogenetic role, and/or on their capacity to enhance the diagnostic and therapeutic clinical armamentarium.
Dr. Marianna Christodoulou
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- Tregs
- autoimmunity
- cancer
- asthma
- transplantation
- allergy
- immunotherapy
- biomarker
- diagnostics
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.