Xenotransplantation: Targeting Acute Vascular Rejection and Endothelial Activation
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".
Deadline for manuscript submissions: 31 May 2024 | Viewed by 168
Special Issue Editor
Special Issue Information
Dear Colleagues,
Acute vascular rejection (AVR) still presents a major hurdle to long-term xenograft acceptance. Although several transgene combinations and knockouts have been described, xenografts are still undergoing AVR. New insights into innate and adaptive immune responses as well as detailed characterizations of signaling pathways are necessary to further optimize the pigs and protect the xenografts. In this Special Issue, we focus on the role of the endothelium during AVR, including the endothelial glycocalyx and underlying signaling pathways, and investigate new means of overcoming blood coagulation mechanisms and thrombotic microangiopathy (TMA).
Dr. Konrad Fischer
Guest Editor
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Keywords
- endothelial activation
- endothelial protection
- thrombotic microangiopathy
- glycocalyx
- acute vascular rejection
