Role of Oxidized Lipids in Cardiovascular Diseases
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".
Deadline for manuscript submissions: 30 June 2024 | Viewed by 212
Special Issue Editor
Interests: atherosclerosis; lipoprotein; inflammation; antioxidants; oxidative stress; cardiovascular diseases; laboratory medicine and analytical method validation; nutrition and population health
Special Issue Information
Dear Colleagues,
Oxidized lipids play a significant role in the development and progression of cardiovascular diseases (CVDs). Lipids, including cholesterol and triglycerides, are essential components of cell membranes and serve various physiological functions. However, when these lipids undergo oxidative modification, they can contribute to the initiation and propagation of atherosclerosis, a major underlying cause of CVD. Oxidized lipids can trigger an inflammatory response in the arterial walls. Immune cells, such as macrophages, recognize oxLDL as foreign or damaged, and initiate an immune response. This leads to the recruitment of additional immune cells and the formation of foam cells, contributing to plaque formation. Moreover, oxidized lipids are reported to impair the function of endothelial cells that line blood vessels. Endothelial dysfunction is a key early event in the development of atherosclerosis, leading to increased permeability and a pro-inflammatory state and smooth muscle cell proliferation, which contributes to the thickening of the arterial wall and the formation of atherosclerotic lesions. Vulnerable atherosclerotic plaques, containing a high content of oxidized lipids, are more prone to rupture. Rupture exposes plaque contents to the bloodstream, leading to platelet activation and thrombus formation. Thrombosis can result in the blockage of blood vessels, leading to heart attacks or strokes.
The purpose of this Special Issue is to improve our understanding of the role of oxidized lipids in cardiovascular diseases. Original research articles and reviews are welcome.
Dr. Mahdi O. Garelnabi
Guest Editor
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Keywords
- oxidized lipids
- antioxidants
- fatty acids
- lipoproteins
- atherosclerosis
- cardiovascular disease
- inflammation
- oxysterol
- macrophages
- endothelial dysfunction
- smooth muscle cell
- proliferation
