The Role of Oxidative Stress in Ovarian Cancer

Dear Colleagues,

Oxidative stress plays a crucial role in the complex landscape of ovarian cancer, influencing both the development of metastases and the emergence of resistance. The intricate interplay between reactive oxygen species (ROS) and cellular defense mechanisms contributes to the pathogenesis of ovarian cancer and poses challenges in developing treatment strategies. Ovarian cancer (OC) is the deadliest gynecologic malignancy and the fifth leading cause of cancer deaths among women in the USA. Extensive metastasis and frequent relapse are significant contributors to the high mortality and recurrence of OC patients. In the context of ovarian cancer metastases, oxidative stress can facilitate the initiation, progression, and dissemination of cancer cells. ROS, which are generated within the tumor microenvironment, contribute to genetic instability, angiogenesis, and the modulation of signaling pathways that promote metastatic spread. Understanding the specific mechanisms through which oxidative stress influences these processes is essential for devising targeted therapeutic approaches. Furthermore, the emergence of resistance to chemotherapy in ovarian cancer is closely associated with oxidative stress. Cancer cells often adapt to oxidative insults by upregulating antioxidant defense mechanisms, rendering them less susceptible to the cytotoxic effects of treatment. This adaptive response complicates the management of ovarian cancer and underscores the need for innovative strategies that can circumvent or counteract these resistance mechanisms. Exploring the intricate relationship between oxidative stress, ovarian cancer metastases, and resistance is paramount in advancing our understanding of the disease and improving clinical outcomes. In this Special Issue, we will continue to focus on the role of oxidative stress in OC development, diagnostic markers, and antioxidant treatment approaches tailored to the specific characteristics of ovarian cancer patients.

We invite original research articles and reviews focused on oxidative stress in ovarian cancer, metastasis, antioxidant mechanisms, and chemotherapeutic resistance. Topics of interest include, but are not limited to: (1) ROS-mediated signaling pathways; (2) oxidative stress on angiogenesis and metastasis; (3) antioxidant defense mechanisms; (3) oxidative stress and chemotherapeutic resistance; (4) the role of the inflammatory microenvironment; (5) biomarkers of oxidative stress in ovarian cancer; and (6) targeting oxidative stress in therapeutic intervention.

Dr. Subramanyam Dasari
Dr. Venkatesh Pooladanda
Guest Editors

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• ovarian cancer
• reactive oxygen species (ROS)
• metastasis
• antioxidant
• oxidative stress
• chemotherapeutic resistance
• inflammation