Cannabinoid Receptors in the Central Nervous System
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Natural and Bio-derived Molecules".
Deadline for manuscript submissions: closed (31 May 2024) | Viewed by 254
Special Issue Editor
Special Issue Information
Dear Colleagues,
The chemical constituents of cannabis (Cannabis sativa) are collectively referred to as cannabinoids, many of which exhibit potent systemic effects. Cannabinoid receptors 1 and 2 are known as CB1 and CB2, and endogenous ligands for these receptors such as 2-AG (2-Arachidonoyl Glycerol) have been discovered. Since the endocannabinoid system was discovered to be a retrograde synaptic transmitter by three independent laboratories (Profs. Nicoll, Kano, and Regehr) almost simultaneously about 20 years ago, significant progress has been made in this field, including the finding that CB1/CB2 receptors are critical for cognitive functions such as extinction learning and memory acquisition. However, it is still unclear which endocannabinoids play critical roles in the various neural functions. Recently, a new cannabinoid receptor, GPR55, was identified. GPR55, similar to CB1/CB2, is a G-protein-coupled receptor (GPCR) for cannabinoids, though much of its physiological function still remains unknown. Thus, the purpose of this Special Issue is to present ambitious studies that attempt to elucidate the functions of various cannabinoid receptors and their physiological agonists, from new methods and perspectives. We also welcome submissions on preclinical and basic research on cannabinoid receptors as targets for the development of central nervous system drugs, which have attracted much attention in recent years.
Prof. Dr. Yasushi Kishimoto
Guest Editor
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Keywords
- learning and memory
- endocannabinoid system
- cognitive flexibility
- cerebellum
- hippocampus
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