Novel Insights on Cancer Stem Cells

Dear Colleagues,

Cancer stem cells (CSCs) or cancer-initiating cells are an aggressive subpopulation present in a range of 1/1000 to 5–10/100 in the tumor bulk of different cancer types, including thyroid cancer and colorectal cancer, respectively. It has been demonstrated that this subpopulation is endowed with high metastatic potential and characterized by high expression levels of efflux pumps, self-renewal capacity and therapy resistance. Standard treatments fail to effectively impair tumor growth because of the persistence of this small subpopulation. The development of innovative therapeutic approaches that specifically target CSCs is urgently needed.

In this Special Issue entitled “Novel Insights on Cancer Stem Cells”, we encourage the submission of original research papers and reviews regarding the most recent advances focused on unravelling innovative therapeutic strategies targeting CSCs or mechanisms regulating CSC maintenance, epigenetic reprogramming and resistance to therapy.

You may choose our Joint Special Issue in Biomedicines.

Dr. Veronica Veschi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• cancer stem cells
• cancer initiating cells
• stemness
• self-renewal
• therapy resistance
• epigenetic reprogramming