The Role of Glia in Alzheimer's Disease

Dear Colleagues,

Alzheimer's disease (AD) is a devastating neurodegenerative disease and the leading cause of dementia worldwide. AD is characterized by the presence of abnormal protein deposits, inflammation in the brain, vascular changes, necroptosis activation, and associated neuronal loss. Recent advances in genome-wide association studies and single-cell transcriptomic studies from post-mortem brain samples and experimental animal models strongly implicate glial cells in the pathogenesis of AD. Our understanding of glia biology in the disease onset and progression of AD is swiftly evolving.

Therefore, this Biomolecules Special Issue centers around the latest developments concerning the involvement and contributions of glial cells in AD. The subjects covered will encompass, but will not be restricted to, the involvement of glia, including microglia, astrocytes, oligodendrocytes, and Ng2 cells, in AD's pathogenesis and their therapeutic implications. This Special Issue showcases the role of glial cells, their context-dependent neuroprotective and neurotoxic functions, multi-faced cellular states, and their response during the disease. We welcome original contributions and review articles that provide comprehensive overviews of the latest literature. Gaining insights into both the cellular autonomous and non-cell autonomous functions of the glia holds great potential for developing targeted therapies to modulate glial behavior to promote neuroprotection and alleviate the disease.

Dr. Sriram Balusu
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• Alzheimer's disease
• neurodegeneration
• glial cells