Tryptophan-Kynurenine Pathway in Health and Disease

Dear Colleagues,

The biological significance of tryptophan as a source of metabolites other than serotonin has garnered significant attention in recent years. The conversion of tryptophan to biologically active products occurs in various cells of vertebrates and invertebrates, including microbiota. The tryptophan derivatives kynurenines, formed along the “kynurenine pathway”, are known to integrate and modulate a plethora of physiological and pathological processes, including cellular fate, immune response or learning and memory. In consequence, the link between an imbalanced kynurenine pathway and the development of human disorders is now broadly accepted.

The aim of this Special Issue is to present novel data on the role of the tryptophan–kynurenine pathway in the development of human pathologies, with a special emphasis on the brain, cardiovascular and metabolic disorders, and the identification of novel markers and therapeutic approaches.

We encourage colleagues to submit their contributions in the form of original research papers presenting results from a broad range of in vitro and in vivo experiments, as well as from clinical studies. Timely reviews, either systematic or narrative, that present original concepts and are of interest to either broad scientific society or address highly specialized areas, are also welcome. We look forward to receiving your contributions.

Prof. Dr. Tomasz Kocki
Prof. Dr. Ewa M. Urbańska
Guest Editors

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• tryptophan
• kynurenine pathway
• kynurenic acid
• neuropsychiatric disorders
• metabolic disorders