Transcription Factor E2F in Normal and Cancer Cells

Dear Colleagues,

I am pleased to invite you to contribute to this Special Issue “Transcription Factor E2F in Normal and Cancer Cells”. As the principal target of the tumor suppressor pRB, E2F plays crucial roles in many important biological processes such as cell proliferation, DNA repair, tumorigenesis, apoptosis, cellular senescence, tumor suppression, development, differentiation, metabolism, stemness, invasion, metastasis, angiogenesis and others. The main obstacles in the radical treatment of cancers are side effects caused by the damage to normal growing cells. To avoid these side effects, we have to specifically target cancer cells. In almost all cancers, the RB pathway is disabled due to oncogenic changes, and the E2F activity is enhanced. Hence, many of the biological processes mentioned above may be affected and may represent a unique feature of cancer cells, which can be utilized to specifically target cancer cells to avoid side effects.

This Special Issue aims to explore E2F-based changes in cancer cells and also in normal cells upon oncogenic changes, seeking new approaches to specifically target cancer cells. Original research articles and reviews are welcome.

I look forward to receiving your contributions.

Prof. Dr. Kiyoshi Ohtani
Guest Editor

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• E2F
• RB
• p53
• cancer
• tumor suppression