Cellular and Molecular Mechanism of Spermatogenesis

Dear Colleagues,

We are pleased to invite you to submit your manuscript to this Special Issue of “Cellular and Molecular Mechanism of Spermatogenesis”.

Spermatogenesis is a highly regulated cellular process within the seminiferous tubules that is structurally and functionally supported by Sertoli cells and peritubular myoid cells in the testes. This complex and synchronous cellular event consists of mitosis, meiosis, and a morphologic transformation of round haploid spermatids into polarized spermatozoa that carry genetic and epigenetic information to the next generation. Spermatogenesis has high energy demands and depends on both systematic and local hormones, signaling transduction molecules, adequate temperature, and bioenergetic metabolites shared via intercellular bridges of syncytial germ cells. Despite extensive studies carried out on understanding spermatogenesis at the cellular and molecular levels, advances in single-cell multi-omics have opened a new avenue for further deciphering the cellular and molecular mechanisms of spermatogenesis. With a growing body of testicular single-cell multi-omics data available, the molecular pathways discovered by bioinformatics analysis need to be validated and confirmed by experimental model systems in vitro and in vivo. Identification and confirmation of biomolecules regulating spermatogenesis are critically important not only for elucidating the cellular and molecular mechanisms of spermatogenesis but also for developing targeted approaches for male infertility treatment and male contraceptive development.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:

1. Mechanisms of hormonal, genetic, and temperature regulation of germ cell proliferation, differentiation, and death during spermatogenesis.
2. Discover and elucidate the molecular pathways via single-cell multi-omics in testes.
3. Validation and confirmation of the molecular pathways discovered via genomics, transcriptomics, proteomics, metabolomics, and lipidomics approaches in experimental model systems in vitro or in vivo by gene editing, transcriptional interference, and molecular or pharmacologic interventions.
4. Deciphering the cellular and molecular mechanisms of testicular pathological conditions in animal and human testes.
5. Protection, rescue, or suppression of spermatogenesis using biomolecules in experimental animal models.
6. Mitochondrial dynamics and bioenergetic regulation of spermatogenesis.
7. Sertoli cell, blood–testis barrier (BTB), and immunologic regulation of spermatogenesis.
8. Application of biomolecules, biomaterials, and bioengineering for establishing in vitro spermatogenesis.

I look forward to receiving your contributions.

Dr. Yanhe Lue
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• spermatogenesis
• regulation
• biomolecules