Molecular and Biochemical Mechanisms of Age-Related Macular Degeneration, Neuroophthalmological Diseases and Uveitis

Dear Colleagues,

In this Special Issue, papers and review articles are invited to be submitted by authors that provide insight i to the mechanisms of diseases of the eye, such as age-related macular degeneration (AMD) which has two phenotypes: dry and wet. The dry type is characterized by drusen formation and, if left untreated, can cause wet AMD, which is characterized by neovascularization from existing choroidal vessels. AMD is a complex disease; several other factors (other than complement factors) are responsible for the pathogenesis of AMD. The complement pathway (alternative pathway) plays an important role in the pathogenesis of AMD. An efficient and less-invasive (compared to a laser-induced CNV model) polyethylene glycol (PEG) model of choroidal neovascularization (CNV) and retinal degeneration and/or dry AMD has been developed. Adiponectin (APN) peptide 1 is an anti-inflammatory peptide and inhibits dry and wet AMD. Idiopathic anterior uveitis (IAU) is the most frequent form of uveitis in humans. IAU is a sight-threatening disease which is associated with significant morbidity and can currently only be treated symptomatically. Notably, experimental autoimmune anterior uveitis (EAAU), a convenient and reliable animal model of human IAU, is used to understand the etiopathogenesis of this disease. The hallmark features of EAAU include inflammation of the iris and the ciliary body (CB) only, with inflammatory cell infiltration in the anterior chamber of the eye. Neuro-ophthalmology is a very important area to study the optic nerve and other nerve-related diseases of the eye. This Special Issue will also discuss optic nerve-related diseases. 

Prof. Dr. Puran S. Bora
Guest Editor

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• retina
• neovascularization
• age-related macular degeneration
• uveal tissue
• neuro-ocular diseases