Role of the Immune System in Progressive and Degenerative Disorders of the Nervous System
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Medicine".
Deadline for manuscript submissions: closed (28 February 2022) | Viewed by 554
Special Issue Editor
Interests: systemic and organ specific autoimmune diseases; cellular and molecular processes; immune activation and suppression; functional role of molecules; new target-specific interventions; regulation; biological functions; potential therapies
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Neurons, glial and immune cells interact with each other to form a coordinated network that maintains the homeostasis of the central nervous system. However, alterations in the crosstalk between these cells can also lead to neuroinflammation, which plays a pivotal role in neurodegenerative disorders, such as multiple sclerosis, Alzheimer’s disease, amyotrophic lateral sclerosis and Parkinson’s disease. The mechanisms of neuroinflammation are mainly dependent on the activation of microglia, which has important immunomodulatory functions. However, the peripheral immune system also exerts a role in promoting neuroinflammation. In the last decade, much effort has been made to characterize the cellular, molecular, and epigenetic mechanisms that underlie the involvement of the immune responses in neurodegeneration. Understanding these mechanisms could help to develop novel therapeutic interventions for the treatment and management of progressive and neurodegenerative disorders.
This Special Issue welcomes research papers and reviews on relevant aspects of the mechanisms involved in the crosstalk between immune cells and the nervous system, which may underlie the etiopathogenesis of neurodegeneration; this includes the molecular pathways of activation and polarization of microglia, the mediators of the crosstalk between these cells (such as cytokines, chemokines, neuropeptides, and neurotransmitters), and the role of both innate and adaptive peripheral immune cells.
Prof. Paolo Fagone
Guest Editor
Manuscript Submission Information
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Keywords
- Microglia activation
- Microglia phenotypes
- Neurodegeneration
- Neuroinflammation
- Immune system–CNS cross-talk
- Neuron–microglia communication
