New Developments for Efficient Rapid Bioassays

Dear Colleagues,

The priority in the development of modern immune- and biosensors is to reduce the analysis time. However, the transition of specific interactions into a non-equilibrium regime is often accompanied by loss of sensitivity. Therefore, the demanded analyses should be carried out quickly without the use of stationary equipment, while maintaining similar detection limits to those of instrumental laboratory methods (chromatography, electrophoresis, etc.).

The task of this Special Issue is to present new developments in the field of efficient and rapid bioassays. Actively progressing bioanalytical systems such as membrane test strips, homogeneous kits with the generation of fluorescent signals, and portable electrochemical sensors are of particular interest, but other developing methods are relevant as well. Systems using antibodies and alternative receptors (for example, aptamers) are considered as the basis for new biosensors. Correct comparisons of new approaches with traditional methods will allow identifying and quantifying factors that could improve the analytical parameters and drawing conclusions about the range of applicability of the novel strategies. It is important to underlie that the potential and prospects for the widespread application of new bioassays can be established only after a thorough testing, involving specific and sequential stages. We will welcome works presenting solutions to common difficulties that are being encountered in the achievement of ideal biosensors, focusing on:

• right sample preparation (rapid and complete)
• right receptor molecule (with high affinity and specific)
• right interaction mode (providing fast formation of detected complexes);
• right signal generation (through new markers and amplification tools)
• right information output (multiplexity, automated processing and transfer of data).

Prof. Dr. Boris B. Dzantiev
Guest Editor

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