Understanding the Complexities of Anticancer Drugs Resistance

Dear Colleagues,

Anticancer drug resistance is a major challenge in cancer therapy and significantly impacts patient outcomes. Genetic mutations play a pivotal role in drug resistance. Cancer cells acquire mutations that alter their DNA, enabling them to evade the effects of anticancer drugs. These mutations can affect drug targets, drug metabolism, and DNA repair mechanisms, rendering the drugs ineffective. Furthermore, some mutations can activate alternative signaling pathways that bypass the drugs' intended targets. The tumor microenvironment can also contribute to drug resistance by providing a protective niche for cancer cells. Tumor cells interact with immune cells, fibroblasts, and blood vessels, creating a complex network. This interaction can lead to the secretion of factors that promote drug resistance, such as cytokines and growth factors. Additionally, the tumor microenvironment can create physical barriers, such as a dense extracellular matrix, limiting drug penetration into the tumor. Understanding the mechanisms of drug resistance can drive the development of effective cancer treatments, including new drugs, combination therapies, and personalized medicine approaches.  In this Special Issue of Cancers, we welcome original research articles or comprehensive reviews focusing on the complexities of anticancer drug resistance, including the mechanisms involved, the factors contributing to drug resistance, and the strategies to overcome drug resistance.

Dr. Mariarosaria Conte
Dr. Nunzio Del Gaudio
Guest Editors

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