Advances in Acidosis within the Tumor Microenvironment

Dear Colleagues,

The discoveries of the last decade in the field of cancer research have shed light on the important role exerted by the local microenvironment that is established around the tumor mass in reprogramming the tumor cells toward aggressive phenotypes, contributing to disease advancement and metastasis. The term “tumor microenvironment” (TME) is very inclusive; when we discuss the TME, we refer not only to all the cellular and non-cellular stromal components within and surrounding the tumor mass, but also biochemical features such as hypoxia and acidosis that characterize most solid tumors. While hypoxia has been studied and characterized extensively, extracellular acidosis has drawn attention of the scientific community relatively recently, and much is yet to be defined. To date, strong evidence indicates that extracellular acidosis reprograms both cancer and stromal cells toward tumor progression by altering metabolism, therapy response, perfusion, immune surveillance and other key aspects, overall favoring the final metastatic dissemination. The aim of this Special Issue is to collect the most recent discoveries on acidic TME, with mechanistic insights and potential clinical interest.

For this Special Issue, we welcome original research and review articles that provide an overview of this topic.

Dr. Silvia Peppicelli
Dr. Elena Andreucci
Guest Editors

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