Advances in the Management of Oropharyngeal Cancer: Navigating the HPV-Associated Landscape

Dear Colleagues,

We are pleased to introduce this Special Issue dedicated to the comprehensive exploration of the latest advancements in the management of oropharyngeal cancer, a complex and increasingly prevalent malignancy that poses significant challenges to both patients and healthcare providers. Over recent years, the landscape of oropharyngeal cancer has changed dramatically, marked by a notable increase in cases associated with human papillomavirus (HPV) infection. This issue will provide an in-depth examination of various facets of oropharyngeal cancer, encompassing topics ranging from screening and epidemiology to clinical trials, surgical interventions, radiation therapy, surveillance including novel liquid biopsy methods, chemotherapy, complications associated with treatment, reconstructive options, and the management of recurrent and metastatic disease.

Our aim is to offer a multidisciplinary perspective of oropharyngeal cancer management, incorporating the insights of leading experts in the field to present the most up-to-date research findings, clinical guidelines and emerging therapies. We will delve into the evolving landscape of screening and early detection strategies, providing critical insights into improving outcomes through timely diagnosis. Additionally, we will explore the epidemiological trends and risk factors associated with oropharyngeal cancer, with a particular emphasis on the increasing prevalence of HPV-related cases and its impact on disease management and prognosis. Furthermore, this Special Issue will encompass the latest developments in surgical techniques, radiation therapy modalities, chemotherapy regimens and their combinations to optimize treatment outcomes while minimizing the side effects. We will also delve into the challenges posed by complications arising from treatment and the various reconstructive options available to restore function and aesthetics in patients' post-treatment lives. Finally, we will address the complex issues surrounding recurrent and metastatic oropharyngeal cancer, discussing cutting-edge approaches to management and emerging therapeutic options, including those tailored to HPV-positive cases. We believe this compilation of articles will serve as a valuable resource for healthcare professionals and researchers committed to advancing the care and understanding of oropharyngeal cancer in the context of its changing landscape, marked by the increasing incidence of HPV-associated cases.

Dr. Jon Mallen-St Clair
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• oropharyngeal cancer
• human papillomavirus
• clinical trials
• transoral robotic surgery
• epidemiology
• HPV-related oropharyngeal cancer